文献类型：期刊文献

英文题名：Clear Genetic Distinctiveness between Human- and Pig-Derived Trichuris Based on Analyses of Mitochondrial Datasets

作者：Liu, Guo-Hua[1,2];Gasser, Robin B.[3];Su, Ang[1,4];Nejsum, Peter[5,6];Peng, Lifei[7];Lin, Rui-Qing[4];Li, Ming-Wei[8];Xu, Min-Jun[1];Zhu, Xing-Quan[1,2,9]

机构：[1]Chinese Acad Agr Sci, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou Vet Res Inst, Lanzhou, Gansu, Peoples R China;[2]Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China;[3]Univ Melbourne, Dept Vet Sci, Werribee, Vic 3030, Australia;[4]S China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China;[5]Univ Copenhagen, Dept Vet Dis Biol, Frederiksberg, Denmark;[6]Univ Copenhagen, Dept Basic Anim & Vet Sci, Frederiksberg, Denmark;[7]Guangdong Med Coll, Dept Parasitol & Clin Parasitol, Zhanjiang, Guangdong, Peoples R China;[8]Guangdong Ocean Univ, Coll Agr, Dept Vet Med, Zhanjiang, Guangdong, Peoples R China;[9]Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing, Heilongjiang Pr, Peoples R China

年份：2012

卷号：6

期号：2

外文期刊名：PLOS NEGLECTED TROPICAL DISEASES

收录：SCI-EXPANDED(收录号：WOS:000300949200048)、、Scopus(收录号：2-s2.0-84857827799)、WOS

基金：This work was supported, in part, by the Program for Outstanding Scientists in Agricultural Research, the Open Funds of the State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (grant nos. SKLVEB2011KFKT004, SKLVEB2011KFKT011, SKLVEB2010KFKT009, SKLVEB2009KFKT008 and SKLVEB2011KFKT010) and the Yunnan Provincial Program for Introducing High-level Scientists (grant no. 2009CI125). Work in the Gasser Lab was supported mainly by the Australian Research Council (ARC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

外文摘要：The whipworm, Trichuris trichiura, causes trichuriasis in similar to 600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions.