文献类型：期刊文献

英文题名：Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells

作者：Xiao, Zhenbang[1];Yang, Shengtao[2,3];Chen, Jiali[2,3];Li, Chengyong[1,2,4];Zhou, Chunxia[2,3];Hong, Pengzhi[2,3];Sun, Shengli[1];Qian, Zhong-Ji[1,2,4]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[2]Southern Marine Sci & Engn Guangdong Lab, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[4]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518108, Peoples R China

年份：2020

卷号：74

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000576946100006)、、Scopus(收录号：2-s2.0-85090952406)、WOS

基金：The research was funded by the Natural Science Foundation of Guangdong Province (2020A1515011075) and the Yangfan Scarce Top Talent Project of Guangdong Province (201433009). The supported by 2020 Shenzhen International Scientific and technological cooperation R&D project and funded by Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1). In addition, the research was the Fund of Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang, ZJW-2019-07).

语种：英文

外文关键词：Trehalose; Photoaging; Oxidative stress; HaCaT cells; UVB

外文摘要：Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-kappa B signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-beta (TGF-beta)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.