文献类型：期刊文献

英文题名：Anti-Aging Effect of Chitosan Oligosaccharide on D-Galactose-Induced Subacute Aging in Mice

作者：Kong, Song-Zhi[1];Li, Ji-Cheng[1];Li, Si-Dong[1];Liao, Ming-Neng[1];Li, Cheng-Peng[1];Zheng, Pin-Jin[1];Guo, Min-Hui[1];Tan, Wei-Xiang[1];Zheng, Zhao-Hui[1];Hu, Zhang[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2018

卷号：16

期号：6

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000436499000006)、、Scopus(收录号：2-s2.0-85048088106)、WOS

基金：This work was supported by the special foundation for excellent young teachers of Guangdong Ocean University (No. 2014008), the program for scientific research start-up funds of Guangdong Ocean University (No. E15177), the special funds for the cultivation of Guangdong college students' scientific and technological innovation ("climbing program" special funds) (No. pdjhb0240 and No. pdjhb0242), as well as the sailing schemes of "Hai Zhi Fan" for college students' scientific and technological innovation (No. qhjh2017zr11).

语种：英文

外文关键词：chitosan oligosaccharide; D-galactose; subacute aging; anti-aging; anti-oxidant; immune function

外文摘要：Chitosan oligosaccharide (COS), a natural polysaccharide with good antioxidant and anti-inflammatory properties, is the depolymerized product of chitosan possessing various biological activities. The present study was designed to investigate the possible anti-aging effect of COS on the aging model mouse induced by D-galactose (D-gal) and explore the underlying mechanism. In the experiment, 48 male Kunming mice (KM mice) were randomly divided into the normal group, model group, positive group, and low-medium-high dose polysaccharide groups (300, 600, 1200 mg/kg/day). The results showed that COS, by intragastric gavage after subcutaneous injection of D-gal (250 mg/kg/day) into the neck of mice consecutively for eight weeks, gradually recovered the body weight, the activity of daily living, and organ indices of mice, as well as effectively ameliorated the histological deterioration of the liver and kidney in mice triggered by D-gal. To be specific, COS obviously improved the activities of antioxidant enzymes in liver and kidney of KM mice, including catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), as well as decreased malondialdehyde (MDA) levels when compared with those in model group mice. Furthermore, COS not only elevated the diminished levels of serum immunoglobulin G (IgG) and IgM induced by D-gal, but also significantly inhibited the D-gal-caused upregulation of serum alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), uric acid (UA) and creatinine (CREA) levels as compared with those of mice in the model group. These results demonstrate that COS has an obvious anti-aging activity in D-gal-induced subacute aging mice, the mechanism of which, to some extent, is associated with enhancing the antioxidant defenses, reducing oxidative stress, and improving the immune function of aging model mice.