文献类型：期刊文献

英文题名：The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?

作者：Song, Cai[1,2,3];Shieh, Chu-Hsin[2];Wu, Yi-Shyuan[2];Kalueff, Allan[1,4,5,6];Gailcvvad, Siddharth[2];Su, Kuan-Pin[2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Res Inst Marine Drugs & Nutr, Zhanjiang, Peoples R China;[2]China Med Univ & Hosp, Grad Inst Neural & Cognit Sci, Taichung, Taiwan;[3]Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS, Canada;[4]Ural Fed Univ, Inst Chem Technol, Ekaterinburg, Russia;[5]Ural Fed Univ, Inst Nat Sci, Ekaterinburg, Russia;[6]St Petersburg State Univ, Inst Translat Biomed, St Petersburg 199034, Russia

年份：2016

卷号：62

起止页码：41

外文期刊名：PROGRESS IN LIPID RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000376543400003)、、Scopus(收录号：2-s2.0-84955317668)、WOS

基金：The work is supported by a National Natural Science Fund (China 81171118) and MOST (103-2320-B-039-041-MY3, Taiwan) to Cai Song.; Allan V. Kalueff is supported by St. Petersburg State University internal grant 1.38.201.2014, and by Ural Federal University (Government of Russian Federation Act 211, contract 02-A03.21.0006).

语种：英文

外文关键词：Eicosapentaenoic acid; Docosahexaenoic acid; Major depressive disorder; Alzheimer's disease; Inflammation; Neurogenesis

外文摘要：Omega-3 polyunsaturated fatty acids (n-3-PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may improve or prevent some psychiatric and neurodegenerative diseases in both experimental and clinical studies. As important membrane components, these PUFAs benefit brain health by modulating neuroimmune and apoptotic pathways, changing membrane function and/or competing with n-6 PUFAs, the precursors of inflammatory mediators. However, the exact role of each fatty add in neuroimmune modulation and neurogenesis, the interaction between EPA and DHA, and the best EPA:DHA ratios for improving brain disorders, remain unclear. It is also unknown whether EPA, as a DHA precursor, acts directly or via DHA. Here, we discuss recent evidence of EPA and DHA effects in the treatment of major depression and Alzheimer's disease, as well as their potential synergistic action on anti-inflammatory, antioxidant and neurotrophic processes in the brain. We further analyze the cellular and molecular mechanisms by which EPA, DHA or their combination may benefit these diseases. We also outline the limitations of current studies and suggest new genetic models and novel approaches to overcome these limitations. Finally, we summarize future strategies for translational research in this field. (C) 2016 Elsevier Ltd. All rights reserved.