文献类型：期刊文献

英文题名：T-2 toxin impairs male fertility by disrupting hypothalamic-pituitary-testis axis and declining testicular function in mice

作者：Yang, Xu[1];Zhang, Xuliang[1];Yao, Qiucheng[2];Song, Miao[1];Han, Yanfei[1];Shao, Bing[1];Li, Yanfei[1]

机构：[1]Northeast Agr Univ, Dept Heilongjiang Common Anim Dis Prevent & Treat, Key Lab Prov Educ, Harbin 150030, Heilongjiang, Peoples R China;[2]Guangdong Ocean Univ, Coll Agr, Zhanjiang 524000, Peoples R China

年份：2019

卷号：234

起止页码：909

外文期刊名：CHEMOSPHERE

收录：SCI-EXPANDED(收录号：WOS:000488136200095)、、EI(收录号：20192607111197)、Scopus(收录号：2-s2.0-85067884486)、WOS

基金：This work was supported by National Natural Science Foundation of China (31872530).

语种：英文

外文关键词：T-2 toxin; Mice; Testosterone synthesis; Hypothalamic-pituitary-testis axis; Male fertility

外文摘要：T-2 toxin could impair male reproductive function. But, the toxicity mechanism is still unclear. In this study, male Kunming mice were orally administrated with T-2 toxin at the doses of 0, 0.5, 1 or 2 mg/kg body weight for 28 days. The fertility, body weight, reproductive organs volume, daily sperm production (DSP), and sperm malformation rate were detected. The expressions of testosterone (T) biosynthetic enzymes, luteinizing hormone (LH)-receptor, follicle stimulating hormone (FSH)-receptor and androgen binding protein (ABP) in testis were detected. The serum hormone level of gonadotropin-releasing hormone (GnRH), FSH, LH, T and progesterone (P), and the mRNA expression of GnRH, GnRH-receptor, LH and FSH were measured. These results demonstrated that T-2 toxin decreased body weight, reproductive organs volume and DSP, increased sperm malformation rate. T-2 toxin impaired fertility by decreasing the mating index, fertility index, numbers of implantation sites and viable fetuses, and increasing the number of animal with resorptions. Meantime, T-2 suppressed testicular function by inhibiting T biosynthesis and decreasing FSHR, LHR and ABP expression. Furthermore, the serum reproductive hormone contents and key factors expression of hypothalamic-pituitary-testis (HPT) axis were decreased by T-2 toxin. In summary, T-2 toxin impaired the male fertility by disrupting HPT axis and impairing testicular function. (C) 2019 Elsevier Ltd. All rights reserved.