文献类型：期刊文献

英文题名：A Novel Peptide from Abalone (Haliotis discus hannai) to Suppress Metastasis and Vasculogenic Mimicry of Tumor Cells and Enhance Anti-Tumor Effect In Vitro

作者：Gong, Fang[1];Chen, Mei-Fang[1];Zhang, Yuan-Yuan[1];Li, Cheng-Yong[2,3];Zhou, Chun-Xia[1];Hong, Peng-Zhi[1];Sun, Sheng-Li[2];Qian, Zhong-Ji[2,3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518114, Peoples R China

年份：2019

卷号：17

期号：4

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000467307100051)、、Scopus(收录号：2-s2.0-85065446630)、WOS

基金：The research was funded by the Yangfan Scarce Top Talent Project of Guangdong Province (201433009) and the Program for Postgraduate Courses and Education Reform and Scientific Research Start-Up Funds of Guangdong Ocean University (to Zhong-Ji Qian). The supported by Guangdong Tongde Pharmaceutical Co., Ltd and National Engineering Research Center for Modernization of Traditional Chinese Medicine (Lingnan Medicinal Plant Oil Branch) and funded by Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1).

语种：英文

外文关键词：abalone; peptide; vasculogenic mimicry; metastasis; MMPs; HIF-1

外文摘要：Vasculogenic mimicry (VM) formed by tumor cells plays a vital role in the progress of tumor, because it provides nutrition for tumor cells and takes away the metabolites. Therefore, the inhibition of VM is crucial to the clinical treatment of tumors. In this study, we investigated the anti-tumor effect of a novel peptide, KVEPQDPSEW (AATP), isolated from abalone (Haliotis discus hannai) on HT1080 cells by migration, invasion analysis and the mode of action. The results showed that AATP effectively inhibited MMPs by blocking MAPKs and NF-B pathways, leading to the downregulation of metastasis of tumor cells. Moreover, AATP significantly inhibited VM and pro-angiogenic factors, including VEGF and MMPs by suppression of AKT/mTOR signaling. In addition, molecular docking was used to study the interaction of AATP and HIF-1, and the results showed that AATP was combined with an active site of HIF-1 by a hydrogen bond. The effect of AATP on anti-metastatic and anti-vascular in HT1080 cells revealed that AATP may be a potential lead compound for treatment of tumors in the future.