文献类型：期刊文献

中文题名：双齿围沙蚕酶解产物对免疫抑制小鼠的免疫调节作用

英文题名：Immunomodulatory effects of enzymolytic products of Perinereis aibuhitensis in immunosuppressed mice

作者：李丽娟[1];朱国萍[1,2];曹文红[1,2];陈忠琴[1,2];谭明堂[1,2]

机构：[1]广东海洋大学食品科技学院国家贝类加工技术研发分中心(湛江),广东省水产品加工与安全重点实验室,广东省海洋食品工程技术研究中心,广东省海洋生物制品工程实验室,广东湛江524088;[2]大连工业大学海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116034

年份：2025

卷号：40

期号：1

起止页码：76

中文期刊名：大连海洋大学学报

外文期刊名：Journal of Dalian Ocean University

收录：北大核心2023、、北大核心

基金：广东海洋大学博士启动项目(060302042202);山东省高等学校海洋食品药品资源开发新技术研发中心平台项目(SDSY20230011)。

语种：中文

中文关键词：双齿围沙蚕;酶解产物;免疫调节;免疫抑制小鼠

外文关键词：Perinereis aibuhitensis;enzymolytic products;immunomodulation;immunosuppressed mice

中文摘要：为探究双齿围沙蚕(Perinereis aibuhitensis)对免疫抑制小鼠的免疫调节作用,以双齿围沙蚕酶解产物为研究对象,环磷酰胺诱导建立免疫抑制小鼠模型,测定空白组、模型组、样品组(相对分子质量<5000、5000~8000、>8000沙蚕酶解产物)的小鼠体质量、免疫脏器指数、脾脏T淋巴细胞亚群、总白细胞数量及免疫球蛋白质量浓度的变化。结果表明:沙蚕酶解产物3种超滤组分均能提高小鼠免疫脏器指数,增加脾脏T细胞CD^(3e+)的数量,提高免疫球蛋白的质量浓度,均具有一定的免疫功效;其中<5000酶解产物高剂量组免疫功效最佳,可显著性提高小鼠体质量指数、免疫脏器指数及白细胞的总数(P<0.05),极显著性增加脾脏T细胞CD^(3e+)的数量和CD^(4+)/CD^(8a+)的比值(P<0.01),增强浆细胞对免疫球蛋白的分泌效果。研究表明,双齿围沙蚕可改善免疫抑制剂导致的免疫功能损伤,增强免疫抑制小鼠免疫调节作用,具有开发成免疫调节剂的潜力。

外文摘要：The enzymolytic products of Perinereis aibuhitesis were used to explore the immunomodulatory effects of P.aibuhitensis in immunosuppressed mice.The immunosuppressed mouse model was established by using cyclophosphamide induction,and the changes in body mass indexes,immune organ indexes,splenic T lymphocyte subset,total white blood cells,and immunoglobulin concentration of mice in the untreated group,model group,and sample group(the enzymolysis products below<5000,5 to 8000,>8000 in P.aibuhitensis)were measured.The results showed that the three ultrafiltration components of enzymolytic products from P.aibuhitensis could increase the immune organ indexes of mice,the number of CD 3e+on T cells in the spleen,and the concentration of immunoglobulin,all of which have particular immune functions.The high dose of enzymolytic products below<5000 in P.aibuhitensis showed the highest efficacy and significantly increased the body mass indexes,immune organ indexes,and total white blood cells(P<0.05)of the mice.And the number of CD^(3e+)and the ratio of CD^(4+)/CD^(8a+)were significantly increased(P<0.01)and the effect of plasma cells on immunoglobulin secretion was enhanced.Perinereis aibuhitensis can ameliorate the immune impairment induced by immunosuppressants and enhance the immunomodulatory effect in immunosuppressed mice and therefore has the potential for development as an immunomodulator.