文献类型：期刊文献

英文题名：A designed self-microemulsion delivery system for dihydromyricetin and its dietary intervention effect on high-fat-diet fed mice

作者：Lyu, Qiyan[1,2];Chen, Lei;Lin, Shiye[1,2];Cao, Hui[1];Teng, Hui[1]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Engn Lab Marine Biol Prod, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Coll Food Sci & Technol,Guangdong Prov Engn Techno, Zhanjiang 524088, Peoples R China;[2]Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China

年份：2022

卷号：390

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000803030400005)、、EI(收录号：20221912100812)、Scopus(收录号：2-s2.0-85129717263)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32072209) ; the Natural Science Foundation of Guangdong Province (2022A1515010694) ; China Postdoctoral Science Foundation Funded Project (2020M682073) .

语种：英文

外文关键词：Dihydromyricetin; Hyperlipidemia; Metabonomics; Self-microemulsion delivery system

外文摘要：The present study aims to design a self-microemulsion delivery system (d-alpha-tocopheryl polyethylene glycol 1000 succinate - quillaja saponin) to enhance the absorptivity of dihydromyricetin (DMY-S), and to investigate its dietary intervention effect on high-fat-diet (HFD) fed mice. We find DMY-S can inhibit the increase of body weight and fat mass, preventing non-alcoholic fatty liver disease. Compared to the model group, the abundance of mice intestinal flora is mainly changed in certain bacterial genera of Firmicutes and Bacteroides, including norank_f_Muribaculaceae and Blautia. The result of metabolism analysis indicated that the expression levels of cincassiol B, creatine, pantothenic acid and aminobutyric acid in the liver tissues of mice treated with DMY-S showed a down-regulation. The DMY-S prevented hyperlipidemia in HFD mice mainly by affecting different pathways including glycerophospholipid metabolism, sphingolipid metabolism and pantothenate and CoA biosynthesis.