文献类型：期刊文献

英文题名：An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3

作者：Yang, Jing-Ming[1,2];Liu, Ya-Yue[1];Yang, Wen-Cong[1];Ma, Xiao-Xiang[1];Nie, Ying-Ying[2];Glukhov, Evgenia[3];Gerwick, Lena[3];Gerwick, William H.[3];Lei, Xiao-Ling[1];Zhang, Yi[1,2,3]

机构：[1]Guangdong Ocean Univ, Res Inst Marine Drugs & Nutr, Guangdong Prov Engn Lab Marine Biol Prod, Coll Food Sci & Technol,Guangdong Prov Key Lab Aq, Zhanjiang, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Inst Guangdong, Marine Med Res & Dev Ctr, Shenzhen, Peoples R China;[3]Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, San Diego, CA 92103 USA

年份：2020

卷号：84

期号：8

起止页码：1546

外文期刊名：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000550130500003)、、WOS

语种：英文

外文关键词：Soybean; Aspergillus terreus; marine fungus; isoflavone; anti-inflammation

外文摘要：A new isoflavone derivative compound1(psoralenone) was isolated from soybean inoculated with a marine fungusAspergillus terreusC23-3, together with seven known compounds including isoflavones2-6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderatein vitroanti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound2(genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds2, 5(biochanin A),6(psoralenol), and7exhibited potent larvicidal activity against brine shrimp. Compounds3(daidzein),4(4MODIFIER LETTER PRIME-hydroxy-6,7-dimethoxyisoflavone), and5-7showed broad-spectrum anti-microbial activity, and compound7also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.