文献类型：期刊文献

英文题名：Modulation of the gut microbiota alleviates insulin resistance in type 2 diabetic mice by daucosterol from Eleocharis dulcis peel

作者：Yang, Xiaomei[1];Gu, Yipeng[1,2];Liu, Huazhong[3];Shang, Feifei[1];Koyama, Tomoyuki[2]

机构：[1]Hezhou Univ, Inst Food Sci & Technol, Guangxi Key Lab Hlth Care Food Sci & Technol, Hezhou 542899, Peoples R China;[2]Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Tokyo 1088477, Japan;[3]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China

年份：2024

卷号：114

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:001197322000001)、、Scopus(收录号：2-s2.0-85186094992)、WOS

基金：This work was supported by Guangxi Science and Technology Base and Talent Special Project (Guike AD23026036) and the Annual University-Level Research Projects of Hezhou University (2023BSQD08).

语种：英文

外文关键词：Eleocharis dulcis peel; Daucosterol; Type 2 diabetes; Anti -hyperglycemic; Gut microbiota

外文摘要：Daucosterol, a natural saponin from Eleocharis dulcis peel, exhibited anti-hyperglycemic properties. This study investigated daucosterol's effects on glycemic control, insulin resistance, and gut microbiota in type 2 diabetic mice. The results demonstrated that daucosterol treatment reduced fasting glucose, improved glucose intolerance and pancreatic islet damage. It decreased HOMA-IR and increased ISI, indicating enhanced insulin sensitivity. Daucosterol supplementation enriched gut microbiota diversity, including reducing Firmicutes and Desulfobacterota while increasing Bacteroidia. This involved an increase in Enterococcus, Akkermansia, Alistipes, Clostridium_sensu_stricto_1, and Odoribacter, coupled with decreased Aerococcus, Desulfovibrio, and Blautia, improved gut health. Uncultured_bacterium_g_Clostridium_sensu_stricto_1 and Bifidobacterium_pseudolongum were identified as major biomarkers. PICRUSt analysis revealed daucosterol improved the pathways of glycan biosynthesis and metabolism, lipid metabolism, carbohydrate metabolism, and some organismal systems. Therefore, daucosterol act as a potential anti-hyperglycemic agent, improving insulin resistance and optimizing gut microbiota to alleviate type 2 diabetes.