文献类型：期刊文献

英文题名：Influences of immunostimulants on phagocytes in cultured fish: a mini review

作者：Abarike, Emmanuel D.[1,2,3,4];Kuebutornye, Felix K. A.[1,2,3,4];Jian, Jichang[1,2,3];Tang, Jufen[1,2,3];Lu, Yishan[1,2,3];Cai, Jia[1,2,3]

机构：[1]Guangdong Ocean Univ, Coll Fishery, Zhanjiang, Peoples R China;[2]Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang, Peoples R China;[3]Guangdong Higher Educ Inst, Key Lab Control Dis Aquat Anim, Zhanjiang, Peoples R China;[4]Univ Dev Studies, Dept Fisheries & Aquat Resources Management, Tamale, Ghana

年份：2019

卷号：11

期号：4

起止页码：1219

外文期刊名：REVIEWS IN AQUACULTURE

收录：SCI-EXPANDED(收录号：WOS:000495397700014)、、Scopus(收录号：2-s2.0-85053869120)、WOS

基金：Our study was supported by the National Natural Science Foundation of China (31572651), Natural Science Foundation of Guangdong Province (2015A030308020) and 2016A030313748) and Science and Technology Planning Project of Guangdong Province (2015A020209181).

语种：英文

外文关键词：dendrictic cells; immunostimulants; macrophages; mast cells; monocytes; neutrophils

外文摘要：Lower vertebrates like fish mostly depend on innate immunity as the first line of defence against invading pathogens. One of the defence mechanisms in innate immunity for fish is the use of phagocytic cells such as monocytes, macrophages, neutrophils, mast cells and dendritic cells in fighting pathogens. These cellular cells employ a variety of mechanisms in protecting fish including but not limited to; the use of pattern recognition receptors and antigen presenting cells to detect the presence of pathogens in host, neutralising them using measures including; inflammation, production of lysosomal enzymes released into the phagosome to neutralising pathogens and prevention of systemic autoimmunity by apoptosis. Some phagocytic cells play the extra role of serving as a bridge between innate and adaptive immunity in fish. Recent accumulating data showed that phagocyte cell activity in fish could be enhanced by a natural or chemical substance (immunostimulants) that stimulates the immune system in fish principally meant to enhance the immune response mechanisms. In this review, the main focus is on elucidating the distinct phagocytic mechanisms played by monocytes, macrophages, neutrophils, mast cells and dendritic cells as principal phagocytes in immune defence and how their activities are influenced by immunostimulants in cultured fish.