文献类型：期刊文献

英文题名：Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer's Disease

作者：Ouyang, Qian-Qian[1,2];Zhao, Shannon[3];Li, Si-Dong[2];Song, Cai[4,5]

机构：[1]Guangdong Ocean Univ, Coll Ocean & Meteorol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China;[3]Univ Southern Calif, Amer Studies & Ethn, Los Angeles, CA 90089 USA;[4]Guangdong Ocean Univ, Res Inst Marine Drugs & Nutr, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[5]Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS B3H 4R2, Canada

年份：2017

卷号：15

期号：11

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000416600200001)、、Scopus(收录号：2-s2.0-85036559252)、WOS

基金：This paper was supported by grants to Cai Song from Natural Science Foundation of China (No.81471223), Dept. Sci. & Tech., Guangdong Province (2016A020215153) and Zhanjiang Key Lab., Dept. Sci. & Tech., Zhanjiang, China (2015A06007).

语种：英文

外文关键词：chitosan; chitooligosaccharide; neuroinflammation; oxidative stress; neuroprotective; Alzheimer's disease

外文摘要：Classic hypotheses of Alzheimer's disease (AD) include cholinergic neuron death, acetylcholine (ACh) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. Increased evidence suggests neuroinflammation and oxidative stress may cause AD. However, none of these factors induces AD independently, but they are all associated with the formation of A and tau proteins. Current clinical treatments based on ACh deficiency can only temporarily relieve symptoms, accompanied with many side-effects. Hence, searching for natural neuroprotective agents, which can significantly improve the major symptoms and reverse disease progress, have received great attention. Currently, several bioactive marine products have shown neuroprotective activities, immunomodulatory and anti-inflammatory effects with low toxicity and mild side effects in laboratory studies. Recently, chitosan (CTS), chitooligosaccharide (COS) and their derivatives from exoskeletons of crustaceans and cell walls of fungi have shown neuroprotective and antioxidative effects, matrix metalloproteinase inhibition, anti-HIV and anti-inflammatory properties. With regards to the hypotheses of AD, the neuroprotective effect of CTS, COS, and their derivatives on AD-like changes in several models have been reported. CTS and COS exert beneficial effects on cognitive impairments via inhibiting oxidative stress and neuroinflammation. They are also a new type of non-toxic -secretase and AChE inhibitor. As neuroprotective agents, they could reduce the cell membrane damage caused by copper ions and decrease the content of reactive oxygen species. This review will focus on their anti-neuroinflammation, antioxidants and their inhibition of -amyloid, acetylcholinesterase and copper ions adsorption. Finally, the limitations and future work will be discussed.