文献类型：期刊文献

英文题名：A non-enzymatic uric acid sensor utilizing ion channels in the barrier layer of a porous anodic alumina membrane

作者：Su, Tiantian[1];He, Lei[2];Mo, Rijian[1];Zhou, Chunxia[1,3];Wang, Zhe[4];Wang, Yi[5];Hong, Pengzhi[1,3];Sun, Shengli[2];Li, Chengyong[2,3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518108, Peoples R China;[4]Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Biomed Mat & Interfaces, Shenzhen 518055, Peoples R China;[5]Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

年份：2018

卷号：96

起止页码：113

外文期刊名：ELECTROCHEMISTRY COMMUNICATIONS

收录：SCI-EXPANDED(收录号：WOS:000448403200023)、、EI(收录号：20184305983231)、Scopus(收录号：2-s2.0-85055151055)、WOS

基金：This work was supported by the National Natural Science Foundation of China (21874029), Science and Technology Planning Project of Guangdong Province (2016A020210114), Guangdong Yangfan Program (201635018), Guangdong Special Support Program (2017TQ04N706), Science and Technology Planning Project of Shenzhen City (JCYJ20170818111719650), Industrial Development Special Funds of Dapeng New Area (KY20170209), Innovation and Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1).

语种：英文

外文关键词：Nanoporous alumina membrane; Barrier layer; Uric acid; Biosensor; Nano-channels; Electrochemistry

外文摘要：Porous anodic alumina (PAA) membranes have attracted considerable interest in biosensor research because they are simple to prepare and the size of the nanochannels can be controlled. However, traditional methods only utilize the porous layer as the barrier layer is removed before use. In this study, we propose a new biosensor for the detection of uric acid based on ion channels in the barrier layer of a PAA membrane. This exhibits a wide linear range (1 nM-0.1 mM) and has excellent selectivity in the presence of interferents (D-(+)-glucose, L-ascorbic acid or dopamine). It is hoped that this new biosensor will prove useful in biological research and clinical medicine.