文献类型：期刊文献

英文题名：Effects of Polyvinyl Chloride Microplastics on the Reproductive System, Intestinal Structure, and Microflora in Male and Female Mice

作者：Yang, Yang-Kai-Xin[1];Ge, Shu-Jun[1];Su, Qi-Ling[1];Chen, Jin-Jun[1];Wu, Jiang[2];Kang, Kai[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Vet Med, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Peoples R China

年份：2024

卷号：11

期号：10

外文期刊名：VETERINARY SCIENCES

收录：SCI-EXPANDED(收录号：WOS:001343519200001)、、Scopus(收录号：2-s2.0-85207432436)、WOS

基金：This work was supported by the Project of the Natural Science Foundation of Guangdong Province, China (Grant No. 2020A1515110362), the Marine Biology Foundation of Zhanjiang Bureau of Science and Technology (Grant No. 2021E05028) and the International Exchange and Cooperation Project of the Science and Technology Department of Guangdong Province (Grant No. K23438).

语种：英文

外文关键词：polyvinyl chloride; microplastics; male and female mice; intestine; reproductive system

外文摘要：The pervasive use of plastics in numerous industrial sectors has resulted in the circulation of microplastics across diverse ecosystems and food chains, giving rise to mounting concerns regarding their potential adverse impacts on biological systems and the environment. The objective of this experiment was to investigate the distinct effects of microplastic-polyvinyl chloride (PVC) exposure on the reproductive system, intestinal tissue structure, and intestinal microbial flora of both male and female mice. A total of 24 4-week-old Kunming mice were randomly assigned to one of four groups: male control group (CM), female control group (CF), male PVC test group (PVCM), and female PVC test group (PVCF) (n = 6). The findings revealed that in terms of the reproductive system, the PVCM group exhibited an impaired testicular structure with an irregular arrangement and a significant reduction in spermatogonia, spermatocytes, and spermatozoa within the seminiferous tubules (p < 0.01). The PVCF group exhibited a notable decrease in ovarian follicles (p < 0.01), accompanied by a reduction in uterus volume, fallopian tube volume, and muscle layer thickness, all of which also decreased significantly (p < 0.01). In comparison to the control groups, exposure to PVC resulted in a reduction in the width and height of the intestinal villi, accompanied by an increase in crypt depth. This led to a significant alteration in the ratio of villus height to crypt depth (V/C) (p < 0.01). Moreover, a reduction in microbial species diversity was observed within both the PVCM and PVCF groups; additionally, it was accompanied by contrasting changes in relative abundance and functional gene profiles among the major intestinal flora constituents. In summary, the findings indicate that PVC induces damage to both male and female mice reproductive and digestive systems, further exhibiting notable sex-dependent effects on mouse intestinal microflora composition, which correlates significantly with its impact on reproductive organs.