文献类型：期刊文献

英文题名：Antimicrobial sodium alginate dressing immobilized with polydopamine-silver composite nanospheres

作者：Liang, Limei[1,2];Hou, Tingting[1];Ouyang, Qianqian[1];Xie, Lei[1];Zhong, Saiyi[3];Li, Puwang[2];Li, Sidong[1];Li, Chengpeng[1]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China

年份：2020

卷号：188

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：SCI-EXPANDED(收录号：WOS:000523557900010)、、EI(收录号：20200808188705)、Scopus(收录号：2-s2.0-85079368063)、WOS

基金：We acknowledge the financial support from the Project of Zhanjiang Science & Technology Plan (2018A206), Enhancing School with Innovation of Guangdong Ocean University (230419108), Innovation and Entrepreneurship Training Team Program of Guangdong Ocean University (521201004029), Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (pdjhb0237, pdjhb2019b0236) and Haizhifan-Qihang Plan of Guangdong Ocean University (qhjhkj201815). This work was also supported in part by National Key Research and Development Project (2019YFD0902005).

语种：英文

外文关键词：Sodium alginate; Polydopamine; Silver nanoparticles; Antimicrobial activity

外文摘要：To endow antibacterial activity and maintain good porosity, oxidized sodium alginate (OSA) sponge was functionalized via polydopamine/silver composite nanospheres (PDA/AgNSs). It is found that uniform PDA spheres (around 1.7 mu m) can be successfully coated on OSA sponge surface without compromise of the OSA sponge integrity and porosity using absolute ethanol as optimized solvent. Particularly, the newly-produced PDA spheres can crosslink with the OSA sponge via the Schiff-base condensation, leading to improved stability. On the other hands, those PDA spheres can be served as the active sites to realize the growth of silver nanoparticles (around 50-70 nm) on PDA spheres surface, leading to the formation of novel PDA/AgNSs. Further analysis indicates that our proposed OSA/PDA/AgNSs sponge shows high blood compatibility, low cell cytotoxicity, good hemostatic performance as well as superior inhibitory activity against P. aeruginosa, S. aureus and E. coli. In conclusions, our proposed strategy opens a new route for antimicrobial sodium alginate dressing development.