文献类型：期刊文献

中文题名：生物相容性聚乳酸基热塑性聚氨酯的合成及性能

英文题名：Synthesis and properties of biocompatible poly(lactide)-based thermoplastic polyurethanes

作者：吕瑞雪[1];张佳琳[1];张慧琳[1];曲炳良[1];景占鑫[1];肖晓[1]

机构：[1]广东海洋大学化学与环境学院,广东湛江524088

年份：2025

卷号：53

期号：12

起止页码：79

中文期刊名：工程塑料应用

外文期刊名：Engineering Plastics Application

收录：北大核心2023、、北大核心

基金：广东省自然科学基金项目(2023A1515110446,2024A1515011145);广东海洋大学学生创新团队项目(CXTD2023018);湛江市科技计划项目(No.2022A01007)。

语种：中文

中文关键词：聚乳酸;聚氨酯;结晶;立构复合;生物相容性

外文关键词：poly(lactide);polyurethanes;crystallization;stereocomplexation;biocompatibility

中文摘要：为了缓解石化基材料大量使用产生的资源紧缺和环境问题,开发可再生的环境友好型生物基高分子材料是目前的研究热点。聚乳酸(PLA)被认为是最具发展潜力的生物基聚酯之一。基于此,合成了生物基聚乳酸(PLA)-聚(ε-己内酯-共聚-γ-丁内酯)(PCBL)-聚乳酸(PLA)三嵌段,并通过与六亚甲基二异氰酸酯的链扩展反应合成生物相容性PLA基热塑性聚氨酯(L-TPUs或D-TPUs),并对其化学结构、结晶性能、热稳定性进行了分析和表征。结果表明,由于氨基甲酸酯键的生成,成功合成了基于PLA-PCBL-PLA三嵌段共聚物的多嵌段PLA基热塑性聚氨酯。相对于PLA-PCBL-PLA三嵌段共聚物,PLA基热塑性聚氨酯的分子量增加,但结晶能力较差。通过控制右旋PLA(PDLA)嵌段的分子量、L-TPUs/D-TPUs的混合比例可以调控PLA基热塑性聚氨酯的结晶性能。进一步探究了PLA基热塑性聚氨酯的形状记忆性能和水合能力,并分析了其与PDLA嵌段分子量和立构复合化的关系。结果表明,通过调整PLA基热塑性聚氨酯的组成和立构复合化程度可以有效调节PLA基热塑性聚氨酯的形状记忆性能和水合能力。此外,细胞毒性实验证实其具有良好的生物相容性。因此,合成的PLA基热塑性聚氨酯具有宏观性能可控可调、生物相容性好等优点,其在生物医用材料领域具有潜在的应用价值。

外文摘要：In order to alleviate the resource shortage and environmental problems caused by the large use of petrochemical-based materials,the development of renewable and environmentally friendly bio-based polymer materials is a current research hotspot.Poly(lactide)(PLA)is regarded as one of the most promising bio-based polyesters.Bio-based PLA-poly(ε-caprolactone-co-γ-butyrolactone)(PCBL)-PLA triblock copolymers were synthesized,and biocompatible PLA-based thermoplastic polyurethane(L-TPUs or D-TPUs)was synthesized through its chain extension reaction with hexamethylene diisocyanate.Their chemical structure,crystallization properties,and thermal stability were analyzed and characterized.The results indicate that multi-block PLA-based polyurethane based on PLA-PCBL-PLA triblock copolymer is synthesized driven by urethane bonds.Compared with the PLA-PCBL-PLA triblock copolymer,the molecular weight of PLA-based polyurethane increases,but its crystallization ability is relatively poor.The crystallization performance of PLA-based polyurethanes can be controlled by regulating the molecular weight of poly(D-lactide)(PDLA)blocks and the mixing ratio of L-TPUs/D-TPUs.Furthermore,the shape memory performance and hydration capacity of PLA-based polyurethanes were evaluated,and the relationship between its crystallization performance and the molecular weight of PDLA blocks as well as the stereocomplexation of PLA-based polyurethanes was analyzed.The results show that the shape memory performance and hydration capacity of PLA-based thermoplastic polyurethane can be effectively regulated by adjusting the composition and sterocomplex degree.In addition,cytotoxicity experiments confirm that the synthesized PLA-based thermoplastic polyurethanes have good biocompatibility.Therefore,the synthesized PLA-based thermoplastic polyurethanes have the advantages of controllable and adjustable macroscopic properties and good biocompatibility,and it will have potential application value in the field of biomedical materials.