文献类型：期刊文献

英文题名：Characterization of Curcumin/Cyclodextrin Polymer Inclusion Complex and Investigation on Its Antioxidant and Antiproliferative Activities

作者：Chen, Jianping[1,2];Qin, Xiaoming[1];Zhong, Saiyi[1];Chen, Suhua[1];Su, Weiming[1];Liu, Ying[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Modern Agr Sci & Technol Innovat C, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Guangdong, Peoples R China;[3]Guangdong Ocean Univ, Fac Agr Sci, Zhanjiang 524088, Peoples R China

年份：2018

卷号：23

期号：5

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000435204000194)、、Scopus(收录号：2-s2.0-85047176276)、WOS

基金：This work was supported by the National Natural Science Foundation of China (no. 21602034), Natural Science Foundation of Guangdong Province (no. 2016A30310332), Open Foundation of Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety (no. 201617), and the Scientific Research Foundation of Guangdong Ocean University (no. R17034).

语种：英文

外文关键词：curcumin; -cyclodextrin polymer; inclusion complex; antioxidant activity; anticancer activity

外文摘要：The aims of this study were to characterize the curcumin/cyclodextrin polymer inclusion complex using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and UV-vis spectroscopy, and to determine the antioxidant activity of this complex by methods of scavenging 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals assays and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals assays. The inhibitory effect of inclusion complex on A375 cells was also investigated by CCK-8 assay, Annexin-V/PI staining assay, and caspase activity assay. The results showed that the complex exhibited different physicochemical characteristics from that of free curcumin. Moreover, the inclusion complex exhibited novel antioxidant activity by scavenging the ABTS and DPPH free radicals and displayed higher antiproliferative activity on A375 cells. Further investigation revealed that inclusion complex could induce A375 cell apoptosis. These findings suggest that inclusion complex could be developed as a novel natural antioxidant with potential applications in cancer chemoprevention.