文献类型：期刊文献

英文题名：Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43

作者：Chen, Ying[1,2];Liu, Huazhong[3];Huang, Hao[2];Ma, Yuetang[2];Wang, Ruihua[2];Hu, Yong[2];Zheng, Xiufen[2];Chen, Chunmei[2];Tang, Hongfeng[2]

机构：[1]North Sichuan Med Coll, Clin Med Coll 2, Nanchong Cent Hosp, Dept Dermatol, Nanchong, Peoples R China;[2]Southern Med Univ, Peoples Hosp Shunde Foshan 1, Shunde Hosp, Dept Dermatol, Foshan, Peoples R China;[3]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang, Peoples R China

年份：2020

卷号：10

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：SCI-EXPANDED(收录号：WOS:000510911700001)、、Scopus(收录号：2-s2.0-85078289408)、WOS

基金：This research was supported by the Traditional Chinese Medicine Bureau of Guangdong Province (No. 20191317), Foshan Science and Technology Burea (FS0AA-KJ218-1301-0013), Clinical ResearchStart Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education (No. PY2018N114), Scientific ResearchStart Plan of Shunde Hospital, Southern Medical University (No. SRSP2018014), Foshan Shunde Talent Development Service Center (Hongfeng Tang Expert Studio) and Foshan Medical Backbone Talents.

语种：英文

外文关键词：squid ink polysaccharides; fibroblasts; oxidative stress; NADPH oxidase; connexin43

外文摘要：Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H2O2-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectively reduce the fibroblast oxidative damage mediated by the up-regulation of NADPH oxidase and Connexin43. Concurrently, squid ink polysaccharides decrease the ROS induced up-regulation of MMP1 and MMP9 to decrease MMP-mediated skin aging. Therefore, we hypothesize that squid ink polysaccharides play an antioxidant role by inhibiting the expression of NADPH oxidase and connexin43. This provides a new target for the effective clinical prevention and treatment of oxidative skin damage.