文献类型：期刊文献

中文题名：海洋真菌ZJ27次级代谢产物的抑菌活性的研究

英文题名：Antibacterial activity of secondary metabolites of marine fungi ZJ27

作者：肖碧红[1];陈彬[2];雷晓凌[1];佘志刚[2];李学恭[1];徐佳[1]

机构：[1]广东海洋大学食品科技学院,广东湛江524025;[2]中山大学化学与化学工程学院,广东广州510275

年份：2012

卷号：36

期号：3

起止页码：95

中文期刊名：海洋科学

外文期刊名：Marine Sciences

收录：CSTPCD、、北大核心2011、CSCD2011_2012、北大核心、CSCD

基金：国家自然科学基金项目(20972197);广东省自然科学基金项目(9151027501000055);广东省科技计划项目(2010B030600004);广东海洋大学基金项目(E09095)

语种：中文

中文关键词：海洋真菌;次级代谢产物;抑菌活性

外文关键词：marine fungi; secondary metabolites; antibacterial activity

中文摘要：对从南海海藻内生真菌ZJ27次级代谢产物中分离得到的5种化合物进行抑菌活性的研究,采用96孔板法测定化合物对蜡状芽孢杆菌、枯草芽孢杆菌、大肠杆菌、白色葡萄球菌、藤黄八叠球菌、金黄色葡萄球菌等6种细菌的抑制活性,并用生长速率法测定化合物对黑曲霉、尖孢镰刀菌、立枯丝核菌和白色念珠菌等4种真菌的抑制活性。化合物对上述6种细菌均有不同的抑制作用,其中化合物1对枯草芽孢杆菌、白色葡萄球菌和藤黄八叠球菌有很好的抑制作用,MIC值分别为0.1、0.2、0.2μmol/mL。化合物1和2对黑曲霉、尖孢镰刀菌、立枯丝核菌和白色念珠菌也有很好的抑制作用,化合物1对这4种真菌的IC50分别为15.06、3.09、3.68、8.19μmol/mL,化合物2相应的IC50为22.28、21.32、8.18、21.75μmol/mL。化合物1和2作为天然抗菌物质,具有广谱抑菌效果,具有较高的应用潜力和综合开发前景。

外文摘要：The antibacterial activities of five compounds isolated from secondary metabolites of seaweed endo- phytic fungi Z J27 were studied in Bacillus cereu, Bacillus subtilis, Escherichia coli, Staphylococcus albus, Sarcina luteus, and Staphylococcus aureus and the antifungal activities were tested in Aspergillus niger, Fusarium ox- ysporum, Rhizoctonia solani, and Candida albicans by the growth rate method. Different compounds had diffident antibacterial activities in the six bacteria. Compound 1 showed remarkable inhibition of B. subtilis, S. albus and S. luteus with an MIC of 0.1, 0.2, and 0.2 pmol/mL, respectively. Compounds 1 and 2 had notable inhibition of A. niger, F. oxysporum, R. solani and C. albicans, with the IC50 values of compound 1 being 5.06, 3.09, 3.68, and 8.19 μmol/mL and those of compound 2 were 22.28, 21.32, 8.18, and 21.75 μmol/mL. As natural antibacterial substances, Compounds 1 and 2 have a great range of potential utilities and a prospect of development and are worth further study.