文献类型：期刊文献

英文题名：Preparation and evaluation of squid ink polysaccharide-chitosan as a wound-healing sponge

作者：Huang, Na[1];Lin, Jiali[1];Li, Sidong[1];Deng, Yifeng[2];Kong, Songzhi[1];Hong, Pengzhi[3];Yang, Ping[3];Liao, Mingneng[1];Hu, Zhang[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, 1 Haida Rd, Zhanjiang 524088, Peoples R China;[2]Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China

年份：2018

卷号：82

起止页码：354

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：SCI-EXPANDED(收录号：WOS:000414886400040)、、EI(收录号：20173804195866)、Scopus(收录号：2-s2.0-85029585368)、WOS

基金：We gratefully acknowledge the financial support by the Natural Science Foundation of Guangdong Province, P R China (2016A030308009), and the Project of Science and Technology Plan of Guangdong Province (2015A020216019 and 2017A010103023), and the Project of Enhancing School with Innovation of Guangdong Ocean University (2015KQNCX060, GDOU2016050219 and 2015KTSCX053, GDOU2013050221, GDOU2016050255), and Provincial Guangdong Ocean University Undergraduate Training Programs for Innovation and Entrepreneurship (201610566097).

语种：英文

外文关键词：Squid ink polysaccharide; Chitosan; Central composite design-response surface methodology; Hemostasis; Scalds; Skin healing

外文摘要：A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS). The optimized formulation of SIP-CS was as follows: chitosan concentration, 2.29%; squid ink polysaccharide concentration, 0.55%; and calcium chloride concentration, 2.82%, at a volume ratio of 15:5:2. SIP-CS was conducive to sticking on the wound, characterized by the spongy property, strong absorptivity, and tackiness. Rabbit ear arterial, hepatic, and femoral artery hemorrhage experiments indicated that, compared with chitosan dressings and absorbable gelatin, the hemostatic times were shorter and the bleeding volume was smaller. Furthermore, SIP-CS absorbed a large amount of hemocytes, leading to rapid hemostasis. The healing areas and wound pathological sections in scalded New Zealand rabbits indicated that SIP-CS promoted wound healing more rapidly than chitosan and better than commercially available burn cream. Thus, SIP-CS is a good wound healing agent for rapid hemostasis, promoting bum/scalded skin healing, and protecting from wound infection.