文献类型：期刊文献

英文题名：Exploring the roles of excess amino acids, creatine, creatinine, and glucose in the formation of heterocyclic aromatic amines by UPLC-MS/MS

作者：Zhang, Haolin[1,2];Lv, Xiaomei[2];Su, Weiming;Chen, Bing-Huei[3];Lai, Yu-Wen[3];Xie, Ruiwei[2];Lin, Qiuyi;Chen, Lei[2];Cao, Hui[2]

机构：[1]Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China;[3]Fu Jen Catholic Univ, Dept Food Sci, New Taipei 24205, Taiwan

年份：2024

卷号：446

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001197284500001)、、EI(收录号：20241015680210)、Scopus(收录号：2-s2.0-85186488273)、WOS

基金：The present work was supported by National Natural Science Foundation of China (NSFC, Grant No. 32061160477, 31972072, 32272315) .

语种：英文

外文关键词：Carcinogen; Excess addition; Precursor; Inhibitor; Formation mechanism; LC-MS

外文摘要：The prevention and control of heterocyclic aromatic amines (HAA) formation to mitigate of potential risks to humans, can be achieved by targeting their precursors. In this study, the detailed roles of individual and excess component (20 common alpha-amino acids, creatine, creatinine, and glucose) on HAA formation in roasted beef patties were examined using UPLC-MS/MS. The results confirmed the reported classical precursors of HAAs. Some components regulated the competitive production of Norharman and Harman. Glycine (Gly) and glucose favored Norharman formation, while cysteine (Cys) and phenylalanine (Phe) for Harman. Serine (Ser) and threonine (Thr) were identified as potential precursors for IQx-type HAAs. Interestingly, methionine (Met), Gly, Thr, Cys, alanine (Ala), and Ser were revealed as more targeted underlying precursors for 1,6-DMIP and 1,5,6TMIP, and the formation mechanism was inferred. Furthermore, Pro, Leu, His, Ile, Lys and Asp were considered as great inhibitors for HAAs.