文献类型：期刊文献

英文题名：Biocompatible double network poly(acrylamide-: Co-acrylic acid)-Al3+/poly(vinyl alcohol)/graphene oxide nanocomposite hydrogels with excellent mechanical properties, self-recovery and self-healing ability

作者：Jing, Zhanxin[1]; Xian, Xueying[1]; Huang, Qiuhong[1]; Chen, Qiurong[1]; Hong, Pengzhi[1]; Li, Yong[1]; Shi, Aihua[2]

机构：[1] College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China; [2] National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China

年份：2020

卷号：44

期号：25

起止页码：10390

外文期刊名：New Journal of Chemistry

收录：EI(收录号：20203509113272)、Scopus(收录号：2-s2.0-85089907221)

语种：英文

外文关键词：Free radical polymerization - pH sensors - Swelling - Carboxylic acids - Nanocomposites - Dynamics - Self-healing materials - Graphene - Tensile strength - Amides - Biocompatibility - Free radicals - Tissue engineering

外文摘要：In this study, we have fabricated poly(acrylamide-co-acrylic acid)-Al3+/poly(vinyl alcohol)/graphene oxide (PAmAA-Al3+/PVA/GO) double network nanocomposite hydrogels by free-radical polymerization and a freeze-thaw cycle in the presence of graphene oxide and aluminum ions. The pH-sensitivity, surface morphology and mechanical properties can be tuned by adjusting the contents of GO, PVA and Al3+. The resulting hydrogels exhibit significant pH-sensitivity and an interconnected pore channel. The PAmAA-Al3+/PVA/GO hydrogels also exhibit high tensile strength, a large elongation at break and high toughness, which is due to the introduction of GO and formation of dynamic reversible bonds. These dynamic reversible bonds formed in the synthesized double network nanocomposite hydrogels could efficiently dissipate energy and recover the three-dimensional network. The combination of nanoparticles, dynamical reversible bonds and the double network structure significantly improves the physicochemical properties of these hydrogels. Finally, subcutaneous implantation of the synthesized nanocomposite hydrogels in mice showed no local inflammatory response, indicating good biocompatibility in vivo. In conclusion, PAmAA-Al3+/PVA/GO double network nanocomposite hydrogels with tunable three-dimensional network structures, mechanical properties, good pH-sensitivity, self-healing ability and biocompatibility are promising biomaterials for tissue engineering. This journal is ? The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.