文献类型：期刊文献

英文题名：Traditional Chinese Medicine Enhances Growth, Immune Response, and Resistance to Streptococcus agalactiae in Nile Tilapia

作者：Abarike, Emmanuel Delwin[1,2,3,4];Jian, Jichang[1,2,3];Tang, Jufen[1,2,3];Cai, Jia[1,2,3];Yu, Huang[1,2,3];Chen, Lihua[5]

机构：[1]Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China;[3]Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang 524088, Peoples R China;[4]Univ Dev Studies, Dept Fisheries & Aquat Resources Management, Tamale Ghana, Peoples R China;[5]Langye Anim Husb Co Ltd, Gaozhou City, Guangdong, Peoples R China

年份：2019

卷号：31

期号：1

起止页码：46

外文期刊名：JOURNAL OF AQUATIC ANIMAL HEALTH

收录：SCI-EXPANDED(收录号：WOS:000461874100004)、、WOS

基金：The authors would like to thank Langye Animal Husbandry and Fishery Breeding of the Science and Technology Company Limited, Gaozhou City, Guangdong Province, for providing fish, feed, and experimental tanks for this research. Finally, the authors would like to thank all colleagues in our laboratory for their inputs. This work was supported by the National Natural Science Foundation of China (31572651), Natural Science Foundation of Guangdong Province (2015A030308020 and 2016A030 313748), and Science and Technology Planning Project of Guangdong Province (2015A020209181). There is no conflict of interest declared in this article.

语种：英文

外文摘要：Herbal supplements are suitable for improving fish health and combating diseases in fish culture. However, the mechanism of action of many herbal mixtures remains unclear. This study was conducted to evaluate the effects of traditional Chinese medicine (TCM; a mix of Astragalus membranaceus, Angelica sinensis, and Crataegus hupehensis at a ratio of 1:1:1 on a weight basis) on growth, immune response, and disease resistance in Nile tilapia Oreochromis niloticus. Experimental fish (mean +/- SE weight = 57 +/- 1 g) were divided into two groups: a control group and a TCM (10 g/kg) group. After 4 weeks of the experimental trial, a significant increase in weight gain and specific growth rate and a lower feed conversion ratio were observed in fish fed a TCM-supplemented diet compared with control fish. Similarly, the immune response of Nile Tilapia in the TCM group showed enhanced lysozyme, superoxide dismutase, catalase, and immunoglobulin levels compared with the control fish. In comparison with the control, fish fed TCM showed significant up-regulation of beta-defensin, lysozyme, heat shock protein 70, superoxide dismutase, and catalase genes in the intestine and head-kidney tissues. After a Streptococcus agalactiae challenge, survival of Nile Tilapia in the TCM group was 70% compared with 35% in the control. These results indicate that the TCM mixture in this study can elevate the immune response and disease resistance of Nile Tilapia.