文献类型：期刊文献

英文题名：Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

作者：Yao, Wanzi[1,2,3];Kong, Qiuhong[1,2];You, Lijun[1,2];Zhong, Saiyi[2];Hileuskaya, Kseniya[4]

机构：[1]South China Univ Technol, Sch Food Sci & Engn, Guangzhou, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Guangdong, Peoples R China;[3]Res Inst Food Nutr & Human Hlth, Ctr 111, Guangzhou, Guangdong, Peoples R China;[4]New Mat Natl Acad Sci Belarus, Inst Chem, Minsk, BELARUS

年份：2023

卷号：4

期号：4

起止页码：1547

外文期刊名：FOOD FRONTIERS

收录：ESCI(收录号：WOS:001031428300001)、Scopus(收录号：2-s2.0-85165340652)、WOS

基金：Program of the Department of Natural Resources of Guangdong Province, Grant/Award Numbers: GDNRC [2021] 49, GDNRC [2021] 53; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2023B1515040014; National Natural Science Foundation of China, Grant/Award Numbers: 22278153, 31972011, 3211101620; Fundamental Research Funds for the Central Universities, Grant/Award Number: 2022ZYGXZR012; Higher Education Discipline Innovation Project, Grant/Award Number: B17018; Belarusian Republican

语种：英文

外文关键词：absorption; brown seaweed polysaccharides; gut microbiota; intestinal barrier; intestinal epithelium

外文摘要：The intestinal barrier is critical in maintaining gut homeostasis and host health. The intestinal barrier dysfunction contributes to intestinal and systemic diseases like inflammatory bowel disease, colorectal cancer, and metabolic syndromes. This review summarizes the physicochemical properties of three main kinds of brown seaweed polysaccharides (BSP), laminarin, fucoidan, and alginate, along with their absorption and metabolism in the intestine and their effects on the intestinal barrier. The physicochemical properties of BSP were closely related to their beneficial effects on intestinal health. BSP were not digested directly in the upper gastrointestinal tract but could be utilized through fermentation by the gut microbiota. BSP kept the integrity of intestinal epithelium by ameliorating intestinal oxidative stress through the nuclear factor erythroid 2-related factor 2 signaling pathway. They also reduced tight junction dysfunction and intestinal permeability and increased the expression of mucins. Moreover, BSP regulated the composition and abundance of gut microbiota and promoted the production of beneficial metabolites such as short-chain fatty acids. This review will help to understand the gut health-promoting functions of the natural compounds derived from brown seaweed and offer a new perspective on intestinal disease prevention and therapy with high effectiveness and safety.