文献类型：期刊文献

英文题名：Characterization of Galectin-2 from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection

作者：Niu, Jinzhong[1,2,3];Huang, Yu[1,2,3,4];Niu, Jimin[1,2,3];Wang, Zhiwen[1,2,3];Tang, Jufen[1,2,3,4];Wang, Bei[1,2,3,4];Lu, Yishan[1,2,3,4];Cai, Jia[1,2,3,4];Jian, Jichang[1,2,3,4]

机构：[1]Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang, Peoples R China;[3]Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang, Peoples R China;[4]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China

年份：2019

卷号：87

起止页码：737

外文期刊名：FISH & SHELLFISH IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000464086600081)、、Scopus(收录号：2-s2.0-85061728564)、WOS

基金：This work was supported by National Natural Science Foundation of China (Grant no. 31572651, 31302226), National Key Research and Development Program of China (2018YFD0900501) and Technology Planning Project of Guangdong Province of China (grant no. 2015A020209181).

语种：英文

外文关键词：Galectin-2; Nile tilapia; Streptococcus agalactiae; Agglutination; Phagocytosis; Immune system

外文摘要：galectin-2 plays important roles in innate and adaptive immunity. In this study, galectin-2 (OnGal 2) was identified from Nile tilapia (Oreochromis niloticus). Its tissue distribution and expression patterns following bacterial infection were also investigated. OnGal-2 is widely distributed in various tissues of healthy tilapia. After Streptococcus agalactiae challenge, OnGal-2 expressions were significantly up-regulated in all tested tissues. Meanwhile, the recombinant OnGal-2 (rOnGal-2) protein showed strong agglutinating activities against both Gram-negative bacteria and Gram-positive bacteria. Moreover, rOnGal-2 could promote phagocytosis of macrophages. Taken together, the present study indicated that OnGal-2 might play roles in the immune responses of Nile tilapia against bacterial pathogens.