文献类型：期刊文献

英文题名：Animal Cloning Applications and Issues

作者：Ibtisham, F.[1];Qadir, M. M. Fahd[2,3];Xiao, M.[1];An, L.[1]

机构：[1]Guangdong Ocean Univ, Agr Collage, Zhanjiang, Guangdong, Peoples R China;[2]Univ Miami, Miller Sch Med, Dept Cell Biol, Miami, FL 33136 USA;[3]Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA

年份：2017

卷号：53

期号：9

起止页码：965

外文期刊名：RUSSIAN JOURNAL OF GENETICS

收录：SCI-EXPANDED(收录号：WOS:000411516900002)、、Scopus(收录号：2-s2.0-85029794800)、WOS

基金：The authors thank to Professor Jinjun Chen for guidance and sharing their valuable knowledge with us. This work was supported by Science and Technology Planning Project of Guangdong Province, China (2010 B090400376).

语种：英文

外文关键词：animal cloning; nuclear transplantation; nuclear reprogramming; transgenic animals; cloning applications; Issues of cloning

外文摘要：Significant progress in the field of biotechnology has allowed for the use of cloning in animals which is being used: to improve genetic makeup, to rescue endangered species, in tissue engineering and to increase farm animal population. Unfortunately, cloning has been met with failure due to a variety of reasons namely early and late abortions, compromised immune systems, circulatory and respiratory problems and a high rate of fetal death. The reasons of these problems are unknown, but may research groups are attempting to understand the underlying molecular and cellular mechanisms involved in cloning efficiency. Atypical epigenetic re-programming appears to be the primary cause of ineffective cloning. Understanding molecular mechanisms involving key regulatory proteins is pivotal in the success of animal cloning. This review shows the current paradigm involving animal cloning efficiency, and also further elucidates applications to improve animal cloning efficiency.