文献类型：期刊文献

英文题名：Theragra chalcogramma Hydrolysates, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Exerts Anti-Photoaging Potential via Targeting MAPK and NF-κB Pathways in SD Rats

作者：Xu, Defeng[1,2];Zhao, Mouming[3];Lin, Haisheng[1];Li, Caihong[4]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[2]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[3]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China;[4]Guangdong Med Univ, Sch Basic Med Sci, Dongguan 523808, Peoples R China

年份：2022

卷号：20

期号：5

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000801951800001)、、WOS

基金：The authors gratefully acknowledge the State Key Research and Development Plan (No. 2017YFD0400200) and the Guangdong Ocean University Ph.D. Startup Project (R17082) for the financial support.

语种：英文

外文关键词：skin photoaging; Theragra chalcogramma; oxidative stress; inflammation; cascading signaling

外文摘要：Previous studies have revealed that excessive exposure to UV irradiation is the main cause of skin photoaging and the signaling pathways of MAPK and NF-kappa B are involved in this progression. The present study aims to investigate the anti-photoaging effects of low molecular weight hydrolysates from Theragra chalcogramma (TCH) and to clarify the underlying mechanism. The degradation of mechanical barrier functions in photoaged skin was substantially ameliorated after TCH administration; meanwhile, TCH significantly elevated the antioxidant capacity and suppressed the over-production of inflammatory cytokine IL-1 beta. Moreover, the histopathological deteriorations such as epidermal hyperplasia and dermal loss were significantly alleviated, along with the increase in procollagen type I content and decrease in MMP-1 activity (p < 0.05). Furthermore, TCH effectively blocked the MAPK and NF-kappa B signaling pathways through inhibition of the phosphorylation of p38, JNK, ERK, i kappa B, and p65 proteins. Collectively, these data indicate that TCH has potential as a novel ingredient for the development of anti-photoaging foods.