文献类型：期刊文献

英文题名：Immune priming in shellfish: A review and an updating mechanistic insight focused on cellular and humoral responses

作者：Yang, Wei[1,2,3,4];Ngoc Tuan Tran[1];Zhu, Chun-Hua[2,3];Yao, De-Fu[1];Aweya, Jude Juventus[1];Gong, Yi[1];Ma, Hong-Yu[1];Zhang, Yue-Ling[1];Li, Guang-Li[2,3];Li, Sheng-Kang[1]

机构：[1]Shantou Univ, Guangdong Prov Key Lab Marine Biotechnol, Shantou 515063, Peoples R China;[2]Guangdong Ocean Univ, Fisheries Coll, Guangdong Res Ctr Reprod Control & Breeding Techn, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Guangdong Prov Engn Lab Mariculture Organism Bree, Zhanjiang 524088, Peoples R China;[4]Yangjiang Polytech, Food & Environm Engn Dept, Yangjiang 529566, Peoples R China

年份：2021

卷号：530

外文期刊名：AQUACULTURE

收录：SCI-EXPANDED(收录号：WOS:000582169700060)、、Scopus(收录号：2-s2.0-85089472423)、WOS

基金：This review was supported by grants from the National Natural Science Foundation of China (41876152, 31850410487, 31802341), Guangdong provincial project of Science and Technology (2017B020204003), Guangdong Basic and Applied Basic Research Foundation (2019A1515110290) and support from Department of Education of Guangdong Province (2017KCXTD014).

语种：英文

外文关键词：Innate immune memory; Antimicrobial activity; Phagocytosis; Hemocyte proliferation; Immune specificity

外文摘要：Immune priming has now been demonstrated as a form of immune memory in a wide range of invertebrate species that lack acquired immune systems. Owing to the specific activation of innate immunity upon reinfection, immune priming has important implications for vaccinating economically valuable shellfish to effectively prevent infectious diseases. To gain a clearer understanding of the underlying mechanisms, extensive research has recently been concentrated on priming responses and better evidence-based mechanistic explanations appear as a prerequisite for the development of prophylactic strategies. This review specially focused on cellular and humoral responses to examine the evidence and inquire into the possible mechanisms involved in broad-spectrum or specific immune priming with particular reference to shellfish, with the aims of providing an overview of the current status of research and helping us better understand the existing knowledge. Current data suggest that both humoral and cellular immune factors are to some extent involved in priming protection, but it is far more likely that cellular immunity is more important in terms of the clearance of pathogens and survival. Antimicrobial peptides and other humoral factors seem to be unable to generate priming specificity, but the only selectivity. Alternatively, the elevated phagocytosis of hemocytes could be linked to the specific recognition of antigens in primed hosts. The molecular mechanism appears to rely upon certain receptors/effectors diversified via alternative splicing that could produce splice variants with specific binding capabilities. Our review concludes that whilst immune priming justifies the theoretical feasibility of 'vaccination' for bacterial and viral disease control, the priming effect and its impact on immune modulation remain to be further clarified. The practicality of vaccine strategy, particularly the benefit and efficiency, also needs reevaluations in the future.