文献类型：期刊文献

英文题名：The risk assessment of Gd₂O₃:Yb³⁺/Er³⁺ nanocomposites as dual-modal nanoprobes for magnetic and fluorescence imaging

作者：Huang, Long[1];Tian, Xiumei[2];Liu, Jun[3];Zheng, Cunjing[1];Xie, Fukang[1];Li, Li[4]

机构：[1]Sun Yat Sen Univ, Dept Histol & Embryol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China;[2]Guangzhou Med Univ, Dept Biomed Engn, Guangzhou 510182, Guangdong, Peoples R China;[3]Guangdong Occan Univ, Sch Elect & Informat Technol, Zhanjiang 524094, Peoples R China;[4]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Imaging Diag & Intervent Ctr, Guangzhou 510060, Guangdong, Peoples R China

年份：2017

卷号：19

期号：2

外文期刊名：JOURNAL OF NANOPARTICLE RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000412350800001)、、WOS

基金：This work was supported by the National Basic Research Program of China (2014CB931700), the National Natural Science Foundation of China (Grant Nos. 81471787, 61471401, 81471711, 81271622, and 11274394), the National Science Foundation for Young Scholars of China (Grant No. 81401462), Natural Science Foundation of Guangdong, China (No. 2014A030311036), and State Key Laboratory of Optoelectronic Materials and Technologies (Sun Yat-Sen Unversity) (No. OEMT-2015-KF-03).

语种：英文

外文关键词：Nanocomposites; Biocompatibility; Immunotoxicity; Magnetic resonance imaging; Tissue targeted imaging; Health effects

外文摘要：Our group has synthesized Gd2O3:Yb3+/Er3+ nanocomposites as magnetic/fluorescence imaging successfully in the previous study, which exhibit good uniformity and monodispersibility with a mean size of 7.4 nm. However, their systematic risk assessment remains unknown. In this article, the in vitro biocompatibility of the Gd2O3:Yb3+/Er3+ was assessed on the basis of cell viability and apoptosis. In vivo immunotoxicity was evaluated by monitoring the product of reactive oxygen species (ROS), clusters of differentiation (CD) markers, and superoxide dismutase (SOD) in Balb/c mice. No significant differences were found in cell viability, apoptosis, and immunotoxicity between our imaging Gd2O3:Yb3+/Er3+ and gadodiamide which are used commonly in clinical. Few nanoprobes were localized in the phagosomes of the liver, heart, lung, spleen, kidney, brain, and tumor under the transmission electron microscopy (TEM) images. In addition, our products reveal good T-1-weighted contrast enhancement of xenografted murine tumor. Therefore, the above results may contribute to the effective application of Gd2O3:Yb3+/Er3+ as molecular imaging contrast agents and dual-modal nanoprobes for cancer detection.