文献类型：期刊文献

英文题名：Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities

作者：Cittrarasu, Vetrivel[1];Kaliannan, Durairaj[2,3];Dharman, Kalaimurugan[2];Maluventhen, Viji[4];Easwaran, Murugesh[5];Liu, Wen Chao[6];Balasubramanian, Balamuralikrishnan[7];Arumugam, Maruthupandian[1]

机构：[1]Periyar Univ, Dept Bot, Sch Life Sci, Ethnopharmacol & Algal Biotechnol Div, Salem 636011, Tamil Nadu, India;[2]Periyar Univ, Sch Life Sci, Dept Environm Sci, Salem 636011, Tamil Nadu, India;[3]Wonkwang Univ, Sch Med, Dept Infect Biol, Zoonosis Res Ctr, Iksan 54538, South Korea;[4]Thiagarajar Coll, Dept Bot, Madurai 625099, Tamil Nadu, India;[5]Int Ctr Genet Engn & Biotechnol, Nutr Improvement Crops, New Delhi 110067, India;[6]Guangdong Ocean Univ, Dept Anim Sci, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China;[7]Sejong Univ, Dept Food Sci & Biotechnol, Coll Life Sci, Seoul 05006, South Korea

年份：2021

卷号：11

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：SCI-EXPANDED(收录号：WOS:000621765800040)、、WOS

基金：The Authors are thankful to the Department of botany Periyar University for providing facilities. The corresponding author gratefully acknowledges University Research Fellowship (URF) in the year 2018-2020 from Center for Bio-diversity and Forest Studies (CBFS), Periyar University and gratefully acknowledge National Nature Science Foundation of China (32002196); Natural Science Foundation of Guangdong Province (2018A030307023), Talent Research Start-up Project of Guangdong Ocean University (R18007, R17103), Innovative Strong School Engineering Youth Talent Project (2017KQNCX090) and Key Platform Projects (2018302) by Department of Education in Guangdong Province for their support and Sejong University, Seoul, Republic of Korea for providing instrumental analysis facility and their support.

语种：英文

外文摘要：The present study is to design an eco-friendly mode to rapidly synthesize selenium nanoparticles (SeNPs) through Ceropegia bulbosa tuber's aqueous extracts and confirming SeNPs synthesis by UV-Vis spectroscopy, FT-IR, XRD, FE-SEM-EDS mapping, HR-TEM, DLS and zeta potential analysis. In addition, to assess the anti-cancer efficacy of the SeNPs against the cultured MDA-MB-231, as studies have shown SeNPs biosynthesis downregulates the cancer cells when compared to normal HBL100 cell lines. The study observed the IC50 value of SeNPs against MDA-MB-231 cells was 34 mu g/mL for 48 h. Furthermore, the SeNPs promotes growth inhibitory effects of certain clinical pathogens such as Bacillus subtilis and Escherichia coli. Apart, from this the SeNPs has shown larvicidal activity after 24 h exposure in Aedes albopitus mosquito's larvae with a maximum of 250 g/mL mortality concentration. This is confirmed by the histopathology results taken at the 4th larval stage. The histopathological studies revealed intense deterioration in the hindgut, epithelial cells, mid gut and cortex region of the larvae. Finally, tried to investigate the photocatalytic activity of SeNPs against the toxic dye, methylene blue using halogen lamp and obtained 96% degradation results. Withal computational study SeNPs was shown to exhibit consistent stability towards breast cancer protein BRCA2. Overall, our findings suggest SeNPs as a potent disruptive agent for MDA-MB-231 cells, few pathogens, mosquito larvae and boosts the photocatalytic dye degradation.