文献类型：期刊文献

英文题名：Amelioration of atherosclerosis in ox-LDL induced HUVEC by sulfated polysaccharides from Gelidium crinale with antihypertensive activity

作者：Zheng, Haiyan[1];Pei, Yu[1];Zhou, Chunxia[1,2];Hong, Pengzhi[1,2];Qian, Zhong-Ji[1,2,3]

机构：[1]Guangdong Ocean Univ, Guangdong Ocean Univ, Coll Food Sci & Technol, Sch Chem & Environm,Shenzhen Inst,Guangdong Prov K, Zhanjiang 524088, Peoples R China;[2]Southern Marine Sci & Engn Guangdong Lab, Zhanjiang 524025, Peoples R China;[3]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China

年份：2023

卷号：228

起止页码：671

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000913973900001)、、EI(收录号：20235015206718)、Scopus(收录号：2-s2.0-85145072252)、WOS

基金：The research was funded by the 2020 Shenzhen International Sci-entific and Technological Cooperation R & D Project (GJHZ20190823111601682) and the Natural Science Foundation of Guangdong Province (2020A1515011075) . The research was supported by the Development Project about Marine Economy Demonstration of Zhanjiang City (XM-202008-01B1) and Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang, ZJW-2019-07) .

语种：英文

外文关键词：Gelidium crinale; Sulfated polysaccharide; Atherosclerosis

外文摘要：Red algal polysaccharide is a good potential medical resource. Different red algal polysaccharides have different structural characteristics and rich biological activities. Previous studies have identified some structural infor-mation of sulfated polysaccharide (GNP, 25.8 kDa) from red algae, Gelidium crinale and found that GNP has excellent anti-inflammatory, antioxidant and anti-tumor activities. On this basis, this study investigated the effect of GNP on atherosclerosis, which is closely related to antioxidant and anti-inflammatory mechanisms and usually coexists and interacts with hypertension. This study investigated the inhibitory activity of GNP on angiotensin-converting enzyme (ACE) and its mechanism on oxidized low-density lipoprotein (ox-LDL)-induced HUVEC atherosclerosis. The results showed that GNP inhibits the up-regulation of cell adhesion molecules and oxidized low-density lipoprotein receptor-1 (LOX-1). GNP can regulate mitogen-activated protein kinases (MAPK), nu-clear factor kappa B (NF-KB) and PI3K/AKT signal pathways, inhibit apoptosis, invasion and migration. Mean-while, GNP (IC50 = 269.2 mu g/mL) antagonizes ACE by competitive binding mode, and it can reduce systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR). It provides a theoretical basis for GNP as a potential substance for the prevention and treatment of atherosclerosis.