文献类型：期刊文献

中文题名：羧甲基壳聚糖/海藻酸钠复合止血微球制备工艺研究

英文题名：Study on the preparation of the composite hemostatic microspheres of carboxymethyl chitosan/sodium alginate

作者：程佳儿[1];卢思彤[1];胡章[1];李思东[1];廖铭能[1]

机构：[1]广东海洋大学化学与环境学院应用化学系,广东湛江524088

年份：2018

卷号：47

期号：3

起止页码：501

中文期刊名：应用化工

外文期刊名：Applied Chemical Industry

收录：CSTPCD、、CSCD_E2017_2018、北大核心2017、北大核心、CSCD

基金：广东省自然科学基金重大基础研究培育项目(2016A030308009);广东省科技计划项目(2015A020216019)

语种：中文

中文关键词：复合止血微球;羧甲基壳聚糖;海藻酸钠;响应面法

外文关键词：composite hemostatic microspheres;carboxymethyl chitosan;sodium alginate;response surface methodology

中文摘要：采用羧甲基壳聚糖和海藻酸钠为基质原料,以戊二醛与氯化钙为复合交联剂,采用乳化交联法制备复合止血微球。以其溶胀率为指标,通过单因素实验研究复合止血微球制备的影响因素;基于单因素实验结果,采用BoxBehnken响应面法(RSM)优化制备工艺。结果表明,复合微球的最佳工艺条件为:羧甲基壳聚糖/海藻酸钠质量比为1∶1,5%氯化钙8 mL,乳化剂Span-80浓度2%。在此条件下,复合微球的溶胀率为302.62%,具有显著的体外促凝血活性。

外文摘要：The composite hemostatic microspheres of carboxymethyl chitosan/sodium alginate were prepared by an emulsion cross-linking method with carboxymethyl chitosan/sodium alginate as the raw materials and glutaraldehyde and calcium chloride as the composite crosslinkers.The factors influencing the preparation of composite hemostatic microspheres were investigated by single factor test with the swelling ratio as an index.On the basis of single factor test results,the experiments were designed by Box-Behnken and the preparation process of the composite hemostatic microspheres was optimized by response surface methodology(RSM).The results indicated that the optimum process conditions were obtained as follows:mass ratio of carboxymethyl chitosan and sodium alginate 1∶1,volume of 5%calcium chloride 8 mL,and concentration of the emulsifier 2%.The composite hemostatic microspheres were prepared under the optimal conditions and the swelling ratio of the microspheres reached 302.62%.The hemostatic activity in vitro demonstrated that the composite microspheres possessed significant procoagulant capacity.