文献类型：期刊文献

英文题名：Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant

作者：Yang, Wen-Cong[1];Bao, Hai-Yan[1,2];Liu, Ya-Yue[1];Nie, Ying-Ying[1,3];Yang, Jing-Ming[1];Hong, Peng-Zhi[1,3];Zhang, Yi[1,3]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Engn Lab Marine Biol Prod, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Res Inst Marine Drugs & Nutr,Coll Food Sci & Tech, Zhanjiang 524088, Peoples R China;[2]Dalian Jiaotong Univ, Sch Environm & Chem Engn, Dalian 116028, Peoples R China;[3]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China

年份：2018

卷号：23

期号：9

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000447365100156)、、WOS

基金：This work was supported by the Yangfan Talent Project of Guangdong Province (201433009), the Natural Science Foundation of Guangdong Province (2018A030307046), the Free Exploration Project of the Shenzhen Fund for Basic Research (JCYJ20170306165013264), the Program for Scientific Research Start-Up Funds of Guangdong Ocean University (GDOU) (E15155), the Applied S & T Research and Development Major Project of Guangdong Province (2016B020235001), the China Postdoctoral Science Foundation (2012T50258) and the Scientific Fund of the Zhanjiang Municipal Oceanic and Fishery Bureau (A18018).

语种：英文

外文关键词：depsidones; Aspergillus unguis; chemical induction; plasma-induced mutant; docking

外文摘要：A new depsidone derivative (1), aspergillusidone G, was isolated from a marine fungus Aspergillus unguis, together with eight known depsidones (2-9) and a cyclic peptide (10): agonodepside A (2), nornidulin (3), nidulin (4), aspergillusidone F (5), unguinol (6), aspergillusidone C (7), 2-chlorounguinol (8), aspergillusidone A (9), and unguisin A (10). Compounds 1-4 and 7-9 were obtained from the plasma induced mutant of this fungus, while 5, 6, and 10 were isolated from the original strain under chemical induction. Their structures were identified using spectroscopic analysis, as well as by comparison with literature data. The HPLC fingerprint analysis indicates that chemical induction and plasma mutagenesis effectively influenced the secondary metabolism, which may be due to their regulation in the key steps in depsidone biosynthesis. In bioassays, compound 9 inhibited acetylcholinesterase (AChE) with IC50 in 56.75 mu M. Compounds 1, 5, 7, 8, and 9 showed moderate to strong activity towards different microbes. Compounds 3, 4, and 5 exhibited potent larvicidality against brine shrimp. In docking studies, higher negative CDOCKER interaction energy and richer strong interactions between AChE and 9 explained the greater activity of 9 compared to 1. Chemical induction and plasma mutagenesis can be used as tools to expand the chemodiversity of fungi and obtain useful natural products.