文献类型：期刊文献

英文题名：Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum

作者：Li, Rui[1,2];Zhou, Qing-Ling[1];Chen, Shu-Tong[1];Tai, Min-Rui[1];Cai, Hong-Ying[1];Ding, Rui[3];Liu, Xiao-Fei[1];Chen, Jian-Ping[1];Luo, Lian-Xiang[3];Zhong, Sai-Yi[1,2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Sci & Technol Innovat Ctr Subtrop F, Zhanjiang 524008, Peoples R China;[2]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[3]Guangdong Med Univ, Marine Biomed Res Inst, Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang 524023, Peoples R China

年份：2023

卷号：21

期号：1

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000915306000001)、、Scopus(收录号：2-s2.0-85146777997)、WOS

语种：英文

外文关键词：Sargassum hemiphyllum; fucoidan; chemical characterization; immune-boosting activity; functional food

外文摘要：Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields.