文献类型：期刊文献

英文题名：Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

作者：Yao, Maojun[1,3];Teng, Hui[2,5];Lv, Qiyan[2];Gao, Huifang[2];Guo, Tengming[2];Lin, Yiwen[2];Gao, Sihai[4];Ma, Meihu[3];Chen, Lei[2,5]

机构：[1]Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China;[2]Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China;[3]Huazhong Agr Univ, Coll Food Sci & Technol, Natl Res & Dev Ctr Egg Proc, Wuhan 430070, Hubei, Peoples R China;[4]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Cardiothorac & Vasc Surg, Wuhan 430030, Hubei, Peoples R China;[5]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524025, Peoples R China

年份：2021

卷号：10

期号：2

起止页码：155

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：SCI-EXPANDED(收录号：WOS:000631830600005)、、Scopus(收录号：2-s2.0-85102999005)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 31801459; 31701520), Science and Technology General Projects of Fujian Province (2019J01393), Educational research project for young and middleaged teachers in Fujian Province (JT180116).

语种：英文

外文关键词：Dihydromyricetin; Type 2 diabetes; Hypolipidemic; Hypoglycemic; AMPK/Akt/ GSK-3 beta signaling pathway

外文摘要：Dihydromyricetin (DHM), as a bioactive flavanonol compound, is mainly found in "Tengcha" (Ampelopsis grossedentata) cultivated in south of China. This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus (T2D) rats, which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin. Forty-eight freshly-weaned rats were randomly assigned into the negative control (Blank), low dose (100 mg/kg), medium dose (200 mg/kg), high dose (400 mg/kg), and positive (40 mg/kg, met) groups. Fasting blood glucose and body weight were measured at weekly interval. Oral glucose tolerance tests were performed on days 42. The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects. Moreover, after the DHM treatment, p-Akt and p-AMPK expression was upregulated, and glycogen synthase kinase-3 beta (GSK-3 beta) expression was downregulated, indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/ GSK-3 beta signaling pathway. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.