文献类型：期刊文献

英文题名：Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

作者：Liu, Wen-Chao[1];Zhuang, Di-Pai[1];Zhao, Yue[1];Balasubramanian, Balamuralikrishnan[2];Zhao, Zhi-Hui[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Peoples R China;[2]Sejong Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seoul 05006, South Korea

年份：2022

卷号：20

期号：6

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000815889000001)、、Scopus(收录号：2-s2.0-85131645207)、WOS

基金：This research was funded by National Nature Science Foundation of China (32002196); Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation ("Climbing Program" Special Funds, pdjh2021b0238).

语种：英文

外文关键词：Enteromorpha prolifera; chickens; oxidative stress; inflammatory response; polysaccharides; Nrf2; NF-kappa B pathways

外文摘要：With global warming, heat stress (HS) has become a worldwide concern in both humans and animals. The ameliorative effect of seaweed (Enteromorpha prolifera) derived polysaccharides (SDP) on HS-induced oxidative stress and the inflammatory response of an immune organ (spleen) was evaluated using an animal model (Gallus gallus domesticus). In total, 144 animals were used in this 4-week trial and randomly assigned to the following three groups: thermoneutral zone, HS, and HS group supplemented with 1000 mg/kg SDP. Dietary SDP improved the antioxidant capacity and reduced the malondialdehyde (MDA) of the spleen when exposed to HS, regulated via enhancing nuclear factor erythroid 2-related factor-2 (Nrf2) signaling. Furthermore, the inclusion of SDP reduced the levels of pro-inflammatory cytokines and alleviated HS-induced splenic inflammatory response by suppressing the nuclear factor-kappa B (NF-kappa B) p65 signaling. These findings suggest that the SDP from E. prolifera can be used as a functional food and/or feed supplement to attenuate HS-induced oxidative stress and inflammatory responses of the immune organs. Moreover, the results could contribute to the development of high-value marine products from seaweed for potential use in humans and animals, owing to their antioxidant and anti-inflammatory effects.