文献类型：期刊文献

英文题名：Preparation of chitosan-Cu²⁺/NH₃ physical hydrogel and its properties

作者：Li, Peng[1];Feng, Zhipan[1];Yu, Ziyang[1];Chen, Yu[1];Li, Puwang[2];Yang, Ziming[2];Li, Sidong[3];Jin, Shaohua[1]

机构：[1]Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524001, Peoples R China

年份：2019

卷号：133

起止页码：67

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000472685700009)、、WOS

基金：This work was supported by "the Fundamental Research Funds for the Central Universities" and "the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No: 1630122017011)".

语种：英文

外文关键词：Chitosan; Physical hydrogel; Gaseous ammonia atmosphere; Copper ion; Mechanical property; Antibacterial property

外文摘要：Chitosan (CTS) physical hydrogels crosslinked under gaseous ammonia atmospheres have attracted considerable attentions for their abilities to maximize the biological activities of CTS while maintaining their biocompatibility. However, poor mechanical properties significantly limit their application. The CTS-metal ion complexing hydrogels showed better mechanical properties. However, the formation process is uncontrollable, and the high dosages of metal ions used may cause cytotoxicity. In the present work, CTS-Cu2+/NH3 physical hydrogel with excellent comprehensive properties was prepared by ammonia fumigation and metal ion complexation. Its formation mechanism and structure were investigated. The above physical hydrogel revealed excellent mechanical properties with the mechanical strength up to 030 MPa, significantly higher than CTS/NH3 hydrogel, even at much lower Cu2+ contents. And CTS-Cu2+/NH3 hydrogel is more thermal stable than CTS/NH3 hydrogel. In addition, it exhibited specific killing effects on Pseudomonas aeruginosa. These results suggest that CTS-Cu2 / NH3 physical hydrogel has a great application potential as a wound dressing. (C) 2019 Elsevier B.V. All rights reserved.