文献类型：期刊文献

英文题名：Porphyran from Porphyra haitanensis Enhances Intestinal Barrier Function and Regulates Gut Microbiota Composition

作者：Malairaj, Sathuvan[1,2];Veeraperumal, Suresh[1];Yao, Wanzi[2,3];Subramanian, Mugesh[4];Tan, Karsoon[5];Zhong, Saiyi[1];Cheong, Kit-Leong[1,2]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Sci & Technol Innovat Ctr Subtrop F, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Coll Food Sci & Technol,Guangdong Prov Engn Lab Ma, Zhanjiang 524088, Peoples R China;[2]Shantou Univ, Coll Sci, Dept Biol, Shantou 515063, Peoples R China;[3]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China;[4]Genexia Bioserv, Res & Dev Ctr, Chennai 600045, Tamilnadu, India;[5]Beibu Gulf Univ, Guangxi Key Lab Beibu Gulf Biodivers Conservat, Qinzhou 535011, Peoples R China

年份：2023

卷号：21

期号：5

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000997283900001)、、Scopus(收录号：2-s2.0-85160296519)、WOS

基金：This research was financially supported by the Key-Area Research and Development Program of Guangdong Province (2020B1111030004) and The Innovative Team Program of High Education of Guangdong Province (2021KCXTD021). The Program for Scientific Research Start-up Funds of Guangdong Ocean University (2023).

语种：英文

外文关键词：Porphyra haitanensis; porphyran; intestinal barrier; gut microbiota

外文摘要：In this study, the effects of a homogenous porphyran from Porphyra haitanensis (PHP) on the intestinal barrier and gut microbiota were investigated. The results showed that oral administration of PHP resulted in a higher luminal moisture content and a lower pH environment for the growth of beneficial bacteria in the colon of mice. PHP significantly increased the production of total short-chain fatty acids during the fermentation process. PHP made the intestinal epithelial cells of mice arrange more tidily and tightly with a significant increase in mucosal thickness. PHP also increased the amount of mucin-producing goblet cells and the expression of mucin in the colon, which maintained the structure and function of the intestinal mucosal barrier. Moreover, PHP up-regulated the expression of tight junctions including ZO-1 and occludin, improving the intestinal physical barrier function. The results of 16S rRNA sequencing showed that PHP regulated the composition of gut microbiota in mice, increasing the richness and diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes. This study revealed that the intake of PHP is beneficial for the gastrointestinal tract and PHP could be a potential source of prebiotics in the functional food and pharmaceutical industries.