文献类型：期刊文献

英文题名：Chitosan-iodine complexes: Preparation, characterization, and antibacterial activity

作者：Zhang, Zhaoyu[1];Weng, Boya[1];Hu, Zhang[1];Si, Zhenyu[1];Li, Lefan[1];Yang, Ziming[2];Cheng, Yu[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524001, Peoples R China

年份：2024

卷号：260

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001170295800001)、、EI(收录号：20240515450611)、Scopus(收录号：2-s2.0-85183097192)、WOS

基金：The authors acknowledge the financial support of Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027) , Guangdong Ocean University Undergraduate Innovation Team Project (CXTD2021020) , and National Key Research and Development Program of China (2020YFD0901101) for this work

语种：英文

外文关键词：Chitosan; Iodine; Antibacterial

外文摘要：Bacterial infections have always been a major threat to public health, and the development of effective antibacterial substances from natural polymers is crucial. 2-Aminoisonicotinic acid (AN) was grafted onto chitosan by 1-ethyl-(3-dimethylaminopropyl)carbodiimide-mediated coupling reactions, and then modified chitosan-iodine (CSAN-I) complexes were prepared by solvent-assisted grinding. The samples were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, proton nuclear magnetic resonance spectroscopy, and X-ray diffraction, confirming that CSAN-I complexes had been successfully prepared. Thermogravimetric (TG) analysis indicated that the chemical modification of chitosan and iodine complexation reduced the thermal stability; X-ray photoelectron spectroscopy (XPS) analysis revealed that 81 % of the iodine in CSAN-I complex was in the form of triiodide ions. The iodine contents of three CSAN-I complexes (CSAN-I-1, CSAN-I-2 and CSAN-I-3) were 1.59 +/- 0.22 %, 3.18 +/- 0.26 %, and 5.56 +/- 0.41 %, respectively. The antibacterial effects were evaluated in vitro, and the results indicated that CSAN-I complexes had strong antibacterial activities against both E. coli and S. aureus. In particular, CSAN-I-3 exhibited the best antibacterial effect. In addition, CSAN-I-3 was nontoxic to L929 cells with good cytocompatibility. Therefore, CSAN-I complexes can be considered as promising candidates for wound management in clinical applications.