文献类型：期刊文献

英文题名：From embryo to sexual maturity: chronic BPA exposure under elevated contamination scenarios induces multi-organ toxicity in marine medaka (Oryzias melastigma)

作者：Li, Yangmei[1];Huan, Zhang[1];Lin, Qin[1];Liu, Junyi[1];Xiao, Wenyang[1];Zhang, Ning[1];Li, Zailiang[1];Zhang, Yanping[1];Guo, Yusong[1];Wang, Zhongduo[1];Dong, Zhongdian[1,2,3]

机构：[1]Guangdong Ocean Univ, Key Lab Aquaculture South China Sea Aquat Econ Ani, Coll Fishery, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Fishery, Guangdong Prov Key Lab Pathogen Biol & Epidemiol A, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Coll Fishery, Key Lab Marine Ecol & Aquaculture Environm Zhanjia, Zhanjiang 524088, Peoples R China

年份：2026

卷号：233

外文期刊名：MARINE POLLUTION BULLETIN

收录：SCI-EXPANDED(收录号：WOS:001866100300001)、、EI(收录号：20263521402757)、Scopus(收录号：2-s2.0-105048657903)、WOS

基金：This research was supported by the National Natural Science Foundation of China (41806195), Natural Science Foundation of Guangdong Province (2025A1515010893), program for scientific research start-up funds of Guangdong Ocean University (060302022401), undergraduate innovation team of Guangdong Ocean University (CXTD2023004) and postgraduate education innovation project of Guangdong Ocean University (202650).

语种：英文

外文关键词：Bisphenol A (BPA); Marine Medaka ( Oryzias melastigma ); Hypothalamic-pituitary-gonadal (HPG) axis; Intestinal Microbiota

外文摘要：Bisphenol A (BPA) is a widely distributed endocrine-disrupting chemical in aquatic environments, yet its longterm toxicological effects in marine fish remain insufficiently understood. In the present study, marine medaka (Oryzias melastigma) were chronically exposed to BPA from the embryonic stage to sexual maturity for 140 days, and multiple endpoints were integrated to evaluate developmental performance, adult behavior and growth, histopathological alterations, oxidative stress responses, gene-expression responses, and intestinal microbiota changes. The measured BPA concentrations were 40.4 and 161.9 & micro;g/L. Chronic BPA exposure significantly reduced embryonic heart rate and hatching success at 161.9 & micro;g/L. In adults, BPA exposure was associated with altered spontaneous locomotor activity, and body mass was significantly increased in males at the high concentration. Histopathological analyses revealed hepatocellular vacuolization and lipid accumulation, ovarian follicular atresia, testicular structural disorganization, and intestinal villus damage. In addition, BPA exposure weakened antioxidant defense capacity in a tissue- and sex-dependent manner, as reflected by significant reductions in selected SOD and GSH-Px endpoints. Gene expression analyses further showed treatmentassociated changes in genes related to neural regulation, the hypothalamic-pituitary-gonadal (HPG) axis, hepatic estrogen responsiveness, and intestinal immune and oxidative stress regulation. Moreover, chronic BPA exposure altered intestinal microbial community structure, with females showing more pronounced dysbiosis than males. Overall, these findings characterize the chronic multi-organ hazards of BPA in marine medaka under elevated contamination scenarios.