文献类型：期刊文献

英文题名：EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression

作者：Peng, Zhilan[1,2,3];Zhang, Cai[1,2,3];Yan, Ling[1];Zhang, Yongping[1,2,3];Yang, Zhiyou[1,2,3];Wang, Jiajia[1];Song, Cai[1,2,3]

机构：[1]Guangdong Ocean Univ, Res Inst Marine Drugs & Nutr, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China;[3]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safet, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China

年份：2020

卷号：21

期号：5

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000524908500220)、、Scopus(收录号：2-s2.0-85081690791)、WOS

基金：This study was supported by grants of National Natural Science Foundation of China (No.81471223 and No.81171118), Project of Enhancing School with Innovation of Guangdong Ocean University (GDOU2013050110) and Guangdong Provincial Science and Technology Planning Project of Guangdong Province, China (2016A020215153 and 2016B020235001).

语种：英文

外文关键词：EPA; DHA; depression; neuroinflammation; neurotrophins; microglia; astrocytes; BDNF

外文摘要：Clinical evidence indicated that eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA) in depression treatment. However, possible mechanisms remain unclear. Here, a chronic unpredictable mild stress (CUMS)-induced model of depression was used to compare EPA and DHA anti-depressant effects. After EPA or DHA feeding, depression-like behavior, brain n-3/n-6 PUFAs profile, serum corticosterone and cholesterol concentration, hippocampal neurotransmitters, microglial and astrocyte related function, as well as neuronal apoptosis and survival signaling pathways were studied. EPA was more effective than DHA to ameliorate CUMS-induced body weight loss, and depression-like behaviors, such as increasing sucrose preference, shortening immobility time and increasing locomotor activity. CUMS-induced corticosterone elevation was reversed by bother fatty acids, while increased cholesterol was only reduced by EPA supplement. Lower hippocampal noradrenaline and 5-hydroxytryptamine concentrations in CUMS rats were also reversed by both EPA and DHA supplement. However, even though CUMS-induced microglial activation and associated increased IL-1 beta were inhibited by both EPA and DHA supplement, increased IL-6 and TNF-alpha levels were only reduced by EPA. Compared to DHA, EPA could improve CUMS-induced suppressive astrocyte biomarkers and associated BDNF-TrkB signaling. Moreover, EPA was more effective than DHA to attenuate CUMS-induced higher hippocampal NGF, GDNF, NF-kappa B, p38, p75, and bax expressions, but reversed bcl-2 reduction. This study for the first time revealed the mechanisms by which EPA was more powerful than DHA in anti-inflammation, normalizing astrocyte and neurotrophin function and regulating NF-kappa B, p38 and apoptosis signaling. These findings reveal the different mechanisms of EPA and DHA in clinical depression treatment.