文献类型：期刊文献

英文题名：Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells

作者：Li, Qi[1];Jiang, Baijian[1];Zhang, Zhiqiang[1];Huang, Yongxiong[1];Xu, Zhou[1];Chen, Xinjin[1];Hou, Xitan[2];Cai, Jia[1,3,4];Huang, Yu[1,3,4];Jian, Jichang[1,3,4]

机构：[1]Guangdong Ocean Univ, Coll Fishery, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang, Peoples R China;[2]Jining Med Univ, Inst Forens Med & Lab Med, Jining, Peoples R China;[3]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China;[4]Guangdong Prov Engn Res Ctr Aquat Anim Hlth Assess, Shenzhen, Peoples R China

年份：2022

卷号：13

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000840534000001)、、Scopus(收录号：2-s2.0-85135859588)、WOS

基金：Funding This work was supported by National Natural Science Foundation of China (No. 32073006, 32002426), National Key R&D Program of China (No. 2018YFD0900501), Fund of Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) (No. ZJW-2019-06).

语种：英文

外文关键词：Nile tilapia; serotonin; serotonin receptors; immunomodulation; Streptococcus agalactiae

外文摘要：Serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. Additionally, numerous immunomodulatory functions of serotonin have been discovered in mammals. However, the regulatory role of the serotonin system in fish immunity remains unclear. In this study, various serotonergic markers in Nile tilapia (Oreochromis niloticus) were identified and characterized. The involvement of the serotonin system during bacterial infection was investigated. Moreover, the expression characteristics and specific functions of serotonergic markers within Nile tilapia immune cells were also assessed. Overall, 22 evolutionarily conserved serotonergic marker genes in Nile tilapia were cloned and characterized. Transcriptional levels of these molecules were most abundant in the brain, and their transcripts were induced during Streptococcus agalactiae infection. Nevertheless, few serotonergic markers exist on Nile tilapia immune cells, and no distinct immunomodulation effect was observed during an immune response. The present study lays a theoretical foundation for further investigation of the immunological mechanisms in fish as well as the evolution of the serotonin system in animals.