文献类型：期刊文献

中文题名：羟基红花黄色素A-壳聚糖微球制备工艺研究

英文题名：A Study on Preparation of Hydroxysafflor Yellow A-Chitosan Microspheres

作者：李东东[1];郭世聪[2];孔松芝[2];陈法锦[1];李思东[2];李继城[2]

机构：[1]广东海洋大学海洋与气象学院,广东湛江524088;[2]广东海洋大学化学与环境学院,广东湛江524088

年份：2017

卷号：37

期号：3

起止页码：73

中文期刊名：广东海洋大学学报

外文期刊名：Journal of Guangdong Ocean University

收录：CSTPCD

基金：广东省自然科学基金-博士启动项目(2015A030310360);广东海洋大学优秀青年骨干教师特别资助计划项目(002014);广东海洋大学创新强校工程科研项目(GDOU2016050229)

语种：中文

中文关键词：羟基红花黄色素A;壳聚糖;乳化交联;微球

外文关键词：hydroxysafflor yellow A; chitosan; emulsion crosslinking; microspheres

中文摘要：为探究羟基红花黄色素A-结合壳聚糖(HSYA-CS)微球的最佳制备工艺,采用乳化交联法制备,以微球的表观特征、粒径分布、包封率及载药量作为主要的评价指标,通过单因素考察和正交试验优化微球的最佳制备工艺。结果表明:戊二醛用量2.0 mL、交联温度50℃、投药比1∶5时,所制备的微球大小比较均一,黏连程度小,圆整度高,粒径范围2.0～4.6μm,载药量(6.53±0.42)%,包封率(68.04±0.46)%,正交设计证实上述条件下制备工艺最佳;乳化交联法制备HSYA-CS微球工艺方法稳定可行,产品性状较好,载药量和包封率较高,可为HSYA的临床应用效果的优化提供方法学借鉴。

外文摘要：To optimize the clinical application effect of Hydroxysafflor yellow A(HSYA),HYSA is treated with chitosan(CS)microspheres so as to find out the best preparation technology of HYSA-CS microspheres,in view of the excellent features of CS.In our study,emulsification crosslinking method is used to make HSYA-CS microsheres,and the single factor and orthogonal test are employed to explore the optimal preparation technology,with the assessment indicators such as appearance features,particle size distribution,entrapment rate as well as drug-loading rate.The results showed when the dosage of glutaraldehyde is2.0mL,the curing temperature is50℃,the weight ratio is1:5and the size of the microspheres is uniform,the degree of adhesion is small,the roundness is high,the particle size is2.0-4.6μm,drug loading is(6.53±0.42)%and entrapment efficiency is(68.04±0.46)%.And the orthogonal design confirmed that the optimum preparation technology of HYSA-CS microspheres is obtained under the above conditions.Based on these findings,it is feasible and stable to use this emulsion cross-linking method to get good character microspheres with higher drug loading and encapsulation efficiency.And it can be used as a reference to HSYA clinical application of optimization.