文献类型：期刊文献

英文题名：Heptapeptide Isolated from Isochrysis zhanjiangensis Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

作者：Zheng, Zhaowan[1,2];Xiao, Zhenbang[1,2];He, Yuan-Lin[1,2];Tang, Yanfei[1,2];Li, Lefan[1];Zhou, Chunxia[1,2];Hong, Pengzhi[1,2];Luo, Hui[2,3];Qian, Zhong-Ji[1,2]

机构：[1]Guangdong Ocean Univ, Shenzhen Inst, Coll Food Sci & Technol, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[2]Southern Marine Sci & Engn Guangdong Lab, Zhanjiang 524025, Peoples R China;[3]Guangdong Med Univ, Marine Biomed Res Inst, Zhanjiang 524023, Peoples R China

年份：2021

卷号：19

期号：11

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000725871700001)、、Scopus(收录号：2-s2.0-85119582721)、WOS

基金：Funding The research was funded by the 2020 Shenzhen International Scientific and Technological Cooperation R & D Project (GJHZ20190823111601682) and Guangdong Basic and Applied Basic Research Foundation (2020A1515011075). The supported by the Development Project about Marine Economy Demonstration of Zhanjiang City (XM-202008-01B1) and Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang, ZJW-2019-07).

语种：英文

外文关键词：heptapeptide; photoaging; UVB; MMPs; apoptosis

外文摘要：Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from Isochrysis zhanjiangensis which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from I. zhanjiangensis, exhibits protective effects against UVB-induced damage.