文献类型：期刊文献

英文题名：Oleic Acid Alleviates Cadmium-Induced Oxidative Damage in Rat by Its Radicals Scavenging Activity

作者：Wang, Jingwen[1];Zhang, Yuanyuan[1];Fang, Zhijia[1];Sun, Lijun[1];Wang, Yaling[1];Liu, Ying[1];Xu, Defeng[1];Nie, Fanghong[1];Gooneratne, Ravi[2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Higher Educ Inst,Guangdong Prov Key Lab, Key Lab Adv Proc Aquat Prod,Guangdong Prov Engn T, 1 Haida Rd, Mazhang Dist 524088, Zhanjiang, Peoples R China;[2]Lincoln Univ, Dept Wine Food & Mol Biosci, Ctr Food Res & Innovat, Canterbury 7647, New Zealand

年份：2019

卷号：190

期号：1

起止页码：95

外文期刊名：BIOLOGICAL TRACE ELEMENT RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000468760200012)、、Scopus(收录号：2-s2.0-85054297219)、WOS

基金：This work was supported by the National Natural Science Foundation of China (No. 31701706) and program for scientific research start-up funds of the Guangdong Ocean University (No. R17102).

语种：英文

外文关键词：Oleic acid; Cadmium; Oxidation stress; Antioxidation; Radicals scavenging activity

外文摘要：Toxic heavy metal cadmium wildly pollutes the environment and threats the human health. Effective treatment of cadmium-induced toxicity and organ damage is an important issue. Cadmium causes organ damage through inducing oxidative stress. Our previous study also found oleic acid (OA) synthesis-related gene can confer resistance to cadmium and alleviate cadmium-induced stress in yeast. However, its alleviation mechanism on cadmium stress especially in animals is still unclear. In this study, the alleviative effects of OA on cadmium and cadmium-induced oxidative stress in rats were investigated. Oral administration of 10, 20, and 30 mg/kg/day OA can significantly increase the survival rate of rats intraperitoneally injected with 30 mg/kg/day cadmium continuously for 7 days. Similar to ascorbic acid (AA), OA can significantly reduce the cadmium-induced lipid peroxidation in multiple organs of rats. The investigation of OA on superoxide dismutase (SOD) activity showed that OA increased the SOD activity of cadmium-treated rat organs. More important, OA reduced the level of superoxide radical O2- of cadmium-treated rat organs. And OA exhibited a strong DPPH radicals scavenging activity at dose of 10, 20 and 30 mg/mL, which may contributed to alleviating cadmium-induced oxidative stress. This study revealed that OA could significantly alleviate cadmium stress via reducing cadmium-induced lipid peroxidation and SOD activity inhibition through its radicals scavenging activity.