文献类型：期刊文献

英文题名：Construction of a composite sponge containing tilapia peptides and chitosan with improved hemostatic performance

作者：Ouyang, Qianqian[1,2];Hou, Tingting[1];Li, Chengpeng[1,3];Hu, Zhang[1];Liang, Limei[1];Li, Sidong[1];Zhong, Qingkun[1];Li, Puwang[2]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Guangdong Med Univ, Marine Biomed Res Inst, Publ Serv Platform South China Sea R&D Marine Bio, Zhanjiang 524023, Peoples R China

年份：2019

卷号：139

起止页码：719

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000506421200074)、、EI(收录号：20242616408732)、Scopus(收录号：2-s2.0-85070311876)、WOS

基金：We acknowledge the financial support from the Project of Scientific and Technological Plan of Guangdong Province (2015A020216019, 2017A010103023),Guangdong Provincial Natural Science Foundation of China (2016A030308009, 2018A030307015), Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (PDJHB0237), Graduate Education Innovation Program of Guangdong Ocean University (201829), Project of Enhancing School With Innovation of Guangdong Ocean University (230419108, GDOU2013050221, GDOU2016050255).

语种：英文

外文关键词：Chitosan; Tilapia peptides; Microspheres; Hemostatic sponge

外文摘要：Despite superior hemostasis and repair function, tilapia peptide's application as wounding dressing is greatly limited due to its poor biostability. To expand its application in wounding dressing area, chitosan (CS), with antibacterial activity, biocompatibility and biodegradability, was used to encapsulate tilapia peptides using ionic crosslink method. The results show 10.6w% (loading capacity) of the tilapia peptides are homogenously dispersed in surface or interior of the as-fabricated chitosan/tilapia peptides microspheres (CS/TPM), which leads to greatly improved biostability. In addition, a new composite sponge using CS/TPM as fillers and CS as matrix was then constructed (S-CS/TPM) and used for hemorrhage control. The results indicate that S-CS/TPM can absorb large volume of water, accelerate blood clotting, increase platelet adhesion and promote conversion of fibrinogen to fibrin. Compared with the CS andCS/TPM, the hemostatic efficiency of S-CS/TPM in New Zealand rabbit ear and femoral artery models is much higher. Particularly, the bleeding time was shortened greatly, and the bleeding volume was reduced significantly. In conclusions, our results suggested that S-CS/TPM is a promising hemostatic adjuvant. (C) 2019 Elsevier B.V. All rights reserved.