文献类型：期刊文献

英文题名：A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides

作者：Li, Fangping[1];Luo, Ping[1];Liu, Huazhong[1]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China

年份：2018

卷号：16

期号：4

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000431068000008)、、Scopus(收录号：2-s2.0-85045151588)、WOS

基金：We thank past and present members of our laboratory for their hard work on SIP and its biological activities, appreciate professor Yanqun Li for revising this paper, and are very grateful for support from the National Natural Science Foundation of China (Grant No. 31171667) and the Natural Science Foundation of Guangdong Province, China (Grant No. 2016A030313753).

语种：英文

外文关键词：Sepia ink polysaccharides; chemoprevention; antitumour; chemosensitization; anticoagulation

外文摘要：Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid (Illex argentinus and Ommastrephes bartrami), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as chemotherapeutic ancillary agent or functional food. Based on the current findings on SIP, we have summarized four topics in this review, including: chemopreventive, antineoplastic, chemosensitive, and procoagulant and anticoagulant activities, which are correlative closely with the actions of anticancer agents on cancer patients, such as anticancer, toxicity and thrombogenesis, with the latter two actions being common causes of death in cancer cases exposed to chemotherapeutic agents.