文献类型：期刊文献

中文题名：胰岛发育相关的转录因子

英文题名：Transcription Factors Related to Islet Development

作者：邢小娟[1];效梅[1];丹慧国[1];安立龙[1]

机构：[1]广东海洋大学农学院动物科学系,湛江524088

年份：2013

卷号：35

期号：6

起止页码：852

中文期刊名：中国细胞生物学学报

外文期刊名：Chinese Journal of Cell Biology

收录：CSTPCD、、北大核心2011、北大核心、CSCD、CSCD2013_2014

基金：广东省自然科学基金(批准号:20100915)资助的课题~~

语种：中文

中文关键词：胰腺内分泌祖细胞;胰岛;分化;转录因子;糖尿病

外文关键词：pancreatic endocrine progenitors; islet; differentiation; transcription factor; diabetes

中文摘要：影响胰岛发育的转录因子有Mnx1(motor neuron and pancreas homeobox 1)、Pdx1(pan-creatic and duodenal homeobox 1)、Ngn3(neurogenin 3)、Grg3(groucho-gene-related gene 3)、Nkx2.2(NK2 homeodomain 2)、Nkx6.1(NK6 homeodomain 1)、MafA(v-maf musculoaponeurotic fibro-sarcoma oncogene homolog A)等。在这些转录因子中,Pdx1对胰芽形成、β细胞成熟以及维持β细胞正常功能起关键作用;Ngn3促使胰腺祖细胞向内分泌细胞分化;Mnx1、Nkx2.2、Grg3保证β细胞的表型,抑制β细胞分化为α细胞;Nkx6.1调节β细胞的增殖和分化;MafA具有β细胞特异性,在胰岛素合成、分泌和糖代谢过程中起重要作用。转录因子异常与糖尿病的发生有着非常密切的关系。因此,探讨这些转录因子在胰岛发育中所起的作用对糖尿病的治疗有重要意义。

外文摘要：The development of islet is regulated by several transcription factors： Mnxl （motor neuron and pancreas homeobox 1）, Pdxl （pancreatic and duodenal homeobox 1）, Ngn3 （neurogenin 3）, Grg3 （groucho-generelated gene 3）, Nkx2.2 （NK2 homeodomain 2）, Nkx6.1 （NK6 homeodomain 1）, MafA （v-maf musculoaponeurotic fibrosarcoma oncogene homolog A） and so on. Among these transcription factors, Pdxl plays a critical role in the formation of pancreatic bud, β cell maturation and maintenance of β cell function; Ngn3 expression drives pancreatic progenitors towards endocrine cells; Mnxl, Nkx2.2, Grg3 ensure β cell phenotype, inhibiting the differentiation of β cells to α cells; Nkx6.1 regulates the proliferation and differentiation of β cells; MafA is β cell-specific and plays an important role in the synthesis and secretion of insulin and glycometabolism. Abnormal transcription factors have a very close relationship with the incidence of diabetes. Therefore, to explore the role of these transcription factors during islet development is important to the treatment of diabetes.