文献类型：期刊文献

英文题名：Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs

作者：Xu, Yuewen[1,2];Yin, Fuquan[1,2];Wang, Jialin[1,2];Wu, Pengxin[1,2];Qiu, Xiaoyuan[1,2];He, Xiaolin[1];Xiao, Yimei[1];Gan, Shangquan[1,2]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang, Peoples R China;[2]Guangdong Ocean Univ, Dept Anim Sci, Key Lab Anim Resources & Breed Innovat Western Gua, Zhanjiang, Peoples R China

年份：2024

卷号：11

外文期刊名：FRONTIERS IN VETERINARY SCIENCE

收录：SCI-EXPANDED(收录号：WOS:001176001900001)、、Scopus(收录号：2-s2.0-85186178095)、WOS

基金：The authors would like to thank all people who were involved in the trial. The authors are grateful for the financial support from the Agriculture and Rural Affairs of Guangdong Department.

语种：英文

外文关键词：tea polyphenol; weaned lamb; intestinal barrier; antioxidant capacity; immune function

外文摘要：Introduction: The purpose of this study was to explore the effects of tea polyphenols on growth performance, cytokine content, intestinal antioxidant status and intestinal barrier function of lambs, in order to provide reference for intestinal health of ruminants. Methods: Thirty weaned lambs (average initial weight 9.32 +/- 1.72 kg) were randomly divided into five groups with six lambs in each group. The control group did not add anything but the basic diet mainly composed of Pennisetum and Corn, and the other four groups added 2, 4, 6 g/kg tea polyphenols and 50 mg/kg chlortetracycline to the basic diet, respectively. The experiment lasted for 42 days. Results: Dietary tea polyphenols improved the growth and stress response and reduced intestinal permeability of lambs (p > 0.05), while CTC did not affect the final lamb weight (p > 0.05). Both tea phenols and CTC significantly reduced inflammatory factors and enhanced the immune system (p > 0.05). Dietary tea polyphenols increased villus height, villus height/crypt depth, secretory immunoglobulin A (p > 0.05), and antioxidant enzymes, while decreasing MDA and apoptosis in the intestine (p > 0.05). However, compared with other groups, the content of T-AOC in jejunum did not change significantly (p > 0.05). Tea polyphenols also increased claudin-1 levels in the duodenum, jejunum, and ileum more than CTC (p > 0.05). CTC had a limited effect on the mRNA expression of Occludin and ZO-1, while tea polyphenols increased these in both the duodenum and ileum (p > 0.05). Conclusion: This study demonstrated that tea polyphenols can effectively improve the intestinal barrier of weaned lambs, and that they have anti-inflammatory and antioxidant effects similar to those of antibiotics. Thus, tea polyphenols could be used to replace antibiotics in ensuring safety of livestock products and in achieving the sustainable development of modern animal husbandry.