文献类型：期刊文献

英文题名：pH-responsive ultrasonic self-assembly spinosad-loaded nanomicelles and their antifungal activity to Fusarium oxysporum

作者：Dong, Enming[1];Yang, Ziming[2];Zhou, Chuang[2];Wang, Chao[2];Li, Sidong[3];Ouyang, Qianqian[3];Kong, Lingxue[4];He, Zuyu[2];Xie, Jianghui[2];Li, Puwang[2];Yang, Peihui[1]

机构：[1]Jinan Univ, Coll Chem & Mat, Guangzhou 510000, Guangdong, Peoples R China;[2]Chinese Acad Trop Agr Sci, Inst Agr Prod Proc, Zhanjiang 524001, Peoples R China;[3]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China;[4]Deakin Univ, Ctr Mat & Fiber Innovat, Inst Technol & Res Innovat, Geelong, Vic 3217, Australia

年份：2019

卷号：141

起止页码：123

外文期刊名：REACTIVE & FUNCTIONAL POLYMERS

收录：SCI-EXPANDED(收录号：WOS:000474329100013)、、EI(收录号：20192106960115)、Scopus(收录号：2-s2.0-85065886723)、WOS

基金：This work was supported by National Key R&D Program of China (2018YFD0201100), National Natural Science Foundation (No.21874057), the Natural Science Foundation of Hainan Province (219QN294), the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No.1630122019012, No.1630122017011), and the Natural Science Foundation of Guangdong Province (No. 2018A030313109).

语种：英文

外文关键词：Amphiphilic chitosan; Spinosad; Nanomicelles; Ultrasonication; Self-assembly

外文摘要：In this paper, we synthesized amphiphilic chitosan using one-pot method with the goal to develop delivery system for the natural pesticide spinosad. Chitosan-Isoleucine-Polyethylene glycol methyl ether (CIP) copolymers based nanomicelles (CIPNMs) were prepared by self-assembly with the assistance of ultrasonic treatment and then the spinosad was loaded on the micelles. Sphere-shaped spinosad-loaded CIPNMs (SSD@CIPNMs) with the particle sizes of approximately 454.9 nm were obtained with the CIP co-polymers. The shell of CIPNMs could effectively prevent the photodegradation of spinosad and played a role of protective barrier. In addition, the prepared SSD@CIPNMs not only delayed the release of spinosad but also had a property of pH-responsive. The release rate of SSD@CIPNMs at pH = 6.4 was greater than that of at pH = 7.0. And, the contact angle of SSD@CIPNMs on banana leaves surface was 60.47 degrees, which meant SSD@CIPNMs had a good affinity with banana leaves. Furthermore, SSD@CIPNMs showed higher antifungal activity against Fusarium oxysporum compared with the unencapsulated spinosad at the same drug dose. This work was contribution to the development of nano-drug carrier systems of natural polymer materials, with a great potential for targeted treatment of banana wilt.